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Libraries from natural product-like scaffolds Export

Current Opinion in Chemical Biology, Vol. 8, No. 3. (June 2004), pp. 281-286.

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biogenic_space database diversity hts_results library_design naturel_products opinion screening_library

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Natural products are an attractive source of varied structures that exhibit potent biological activities, and desirable pharmacological profiles. Since the relatively recent advent of high-throughput organic synthesis in the drug discovery process, several design approaches have been applied to the construction of screening libraries. Libraries of natural-product derivatives, natural-product-like compounds prepared by total synthesis, and libraries derived from natural-products are several types that have been reported.


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