Functional classification analysis of somatically mutated genes in human breast and colorectal cancers. Export

@article{citeulike:2869818, abstract = {A recent study published by Sjoblom and colleagues [T. Sjoblom, S. Jones, L.D. Wood, D.W. Parsons, J. Lin, T.D. Barber, D. Mandelker, R.J. Leary, J. Ptak, N. Silliman, S. Szabo, P. Buckhaults, C. Farrell, P. Meeh, S.D. Markowitz, J. Willis, D. Dawson, J.K. Willson, A.F. Gazdar, J. Hartigan, L. Wu, C. Liu, G. Parmigiani, B.H. Park, K.E. Bachman, N. Papadopoulos, B. Vogelstein, K.W. Kinzler, V.E. Velculescu, The consensus coding sequences of human breast and colorectal cancers. Science 314 (2006) 268-274.] performed comprehensive sequencing of 13,023 human genes and identified mutations in genes specific to breast and colorectal tumors, providing insight into organ-specific tumor biology. Here we present a systematic analysis of the functional classifications of Sjoblom's "CAN" genes, a subset of these validated mutant genes, that identifies novel organ-specific biological themes and molecular pathways associated with disease-specific etiology. This analysis links four somatically mutated genes associated with diverse oncological types to colorectal and breast cancers through established TGF-beta1-regulated interactions, revealing mechanistic differences in these cancers and providing potential diagnostic and therapeutic targets.}, address = {Department of Biostatistics and Computational Biology and Department of Cancer Biology, Dana–Farber Cancer Institute, Boston, MA 02115-6084, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA; Department of Statistics, University of Oxford, Oxford, UK.}, author = {Chittenden, T. W. and Howe, E. A. and Culhane, A. C. and Sultana, R. and Taylor, J. M. and Holmes, C. and Quackenbush, J.}, citeulike-article-id = {2869818}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ygeno.2008.03.002}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18434084}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18434084}, day = {21}, doi = {10.1016/j.ygeno.2008.03.002}, issn = {1089-8646}, journal = {Genomics}, keywords = {breast\_cancer, can\_genes, colon\_cancer, functional\_analysis}, month = {June}, number = {6}, pages = {508--511}, posted-at = {2009-07-22 13:57:06}, priority = {0}, title = {Functional classification analysis of somatically mutated genes in human breast and colorectal cancers.}, url = {http://dx.doi.org/10.1016/j.ygeno.2008.03.002}, volume = {91}, year = {2008} }

TY - JOUR ID - citeulike:2869818 L3 - citeulike-article-id:2869818 N2 - A recent study published by Sjoblom and colleagues [T. Sjoblom, S. Jones, L.D. Wood, D.W. Parsons, J. Lin, T.D. Barber, D. Mandelker, R.J. Leary, J. Ptak, N. Silliman, S. Szabo, P. Buckhaults, C. Farrell, P. Meeh, S.D. Markowitz, J. Willis, D. Dawson, J.K. Willson, A.F. Gazdar, J. Hartigan, L. Wu, C. Liu, G. Parmigiani, B.H. Park, K.E. Bachman, N. Papadopoulos, B. Vogelstein, K.W. Kinzler, V.E. Velculescu, The consensus coding sequences of human breast and colorectal cancers. Science 314 (2006) 268-274.] performed comprehensive sequencing of 13,023 human genes and identified mutations in genes specific to breast and colorectal tumors, providing insight into organ-specific tumor biology. Here we present a systematic analysis of the functional classifications of Sjoblom's "CAN" genes, a subset of these validated mutant genes, that identifies novel organ-specific biological themes and molecular pathways associated with disease-specific etiology. This analysis links four somatically mutated genes associated with diverse oncological types to colorectal and breast cancers through established TGF-beta1-regulated interactions, revealing mechanistic differences in these cancers and providing potential diagnostic and therapeutic targets. IS - 6 JF - Genomics SN - 1089-8646 AD - Department of Biostatistics and Computational Biology and Department of Cancer Biology, Dana–Farber Cancer Institute, Boston, MA 02115-6084, USA; Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA; Department of Statistics, University of Oxford, Oxford, UK. EP - 511 TI - Functional classification analysis of somatically mutated genes in human breast and colorectal cancers. VL - 91 SP - 508 KW - breast_cancer KW - can_genes KW - colon_cancer KW - functional_analysis AU - Chittenden, TW AU - Howe, EA AU - Culhane, AC AU - Sultana, R AU - Taylor, JM AU - Holmes, C AU - Quackenbush, J PY - 2008/06/21/ UR - http://dx.doi.org/10.1016/j.ygeno.2008.03.002 ER -