Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Export

@article{citeulike:3655873, abstract = {We have performed a genome-wide analysis of copy number changes in breast and colorectal tumors using approaches that can reliably detect homozygous deletions and amplifications. We found that the number of genes altered by major copy number changes, deletion of all copies or amplification to at least 12 copies per cell, averaged 17 per tumor. We have integrated these data with previous mutation analyses of the Reference Sequence genes in these same tumor types and have identified genes and cellular pathways affected by both copy number changes and point alterations. Pathways enriched for genetic alterations included those controlling cell adhesion, intracellular signaling, DNA topological change, and cell cycle control. These analyses provide an integrated view of copy number and sequencing alterations on a genome-wide scale and identify genes and pathways that could prove useful for cancer diagnosis and therapy.}, author = {Leary, Rebecca J. and Lin, Jimmy C. and Cummins, Jordan and Boca, Simina and Wood, Laura D. and Parsons, D. Williams and Jones, Si\^{a}n and Sj\"{o}blom, Tobias and Park, Ben-Ho H. and Parsons, Ramon and Willis, Joseph and Dawson, Dawn and Willson, James K. and Nikolskaya, Tatiana and Nikolsky, Yuri and Kopelovich, Levy and Papadopoulos, Nick and Pennacchio, Len A. and Wang, Tian-Li L. and Markowitz, Sanford D. and Parmigiani, Giovanni and Kinzler, Kenneth W. and Vogelstein, Bert and Velculescu, Victor E.}, citeulike-article-id = {3655873}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0808041105}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18852474}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18852474}, day = {21}, doi = {10.1073/pnas.0808041105}, issn = {1091-6490}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {breast\_cancer, colon\_cancer, copy-number, gene\_expression, integration, mutation}, month = {October}, number = {42}, pages = {16224--16229}, posted-at = {2008-11-26 17:38:57}, priority = {0}, title = {Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers.}, url = {http://dx.doi.org/10.1073/pnas.0808041105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:3655873 L3 - citeulike-article-id:3655873 N2 - We have performed a genome-wide analysis of copy number changes in breast and colorectal tumors using approaches that can reliably detect homozygous deletions and amplifications. We found that the number of genes altered by major copy number changes, deletion of all copies or amplification to at least 12 copies per cell, averaged 17 per tumor. We have integrated these data with previous mutation analyses of the Reference Sequence genes in these same tumor types and have identified genes and cellular pathways affected by both copy number changes and point alterations. Pathways enriched for genetic alterations included those controlling cell adhesion, intracellular signaling, DNA topological change, and cell cycle control. These analyses provide an integrated view of copy number and sequencing alterations on a genome-wide scale and identify genes and pathways that could prove useful for cancer diagnosis and therapy. IS - 42 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 1091-6490 EP - 16229 TI - Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. VL - 105 SP - 16224 KW - breast_cancer KW - colon_cancer KW - copy-number KW - gene_expression KW - integration KW - mutation AU - Leary, Rebecca AU - Lin, Jimmy AU - Cummins, Jordan AU - Boca, Simina AU - Wood, Laura AU - Parsons, Williams AU - Jones, Siân AU - Sjöblom, Tobias AU - Park, Ben-Ho AU - Parsons, Ramon AU - Willis, Joseph AU - Dawson, Dawn AU - Willson, James AU - Nikolskaya, Tatiana AU - Nikolsky, Yuri AU - Kopelovich, Levy AU - Papadopoulos, Nick AU - Pennacchio, Len AU - Wang, Tian-Li AU - Markowitz, Sanford AU - Parmigiani, Giovanni AU - Kinzler, Kenneth AU - Vogelstein, Bert AU - Velculescu, Victor PY - 2008/10/21/ UR - http://dx.doi.org/10.1073/pnas.0808041105 ER -