Recent advances in systemic therapy. New diagnostics and biological predictors of outcome in early breast cancer Export

@article{citeulike:4272196, abstract = {The key to optimising our approach in early breast cancer is to individualise care. Each patient has a tumour with innate features that dictate their chance of relapse and their responsiveness to treatment. Often patients with similar clinical and pathological tumours will have markedly different outcomes and responses to adjuvant intervention. These differences are encoded in the tumour genetic profile. Effective biomarkers may replace or complement traditional clinical and histopathological markers in assessing tumour behaviour and risk. Development of high-throughput genomic technologies is enabling the study of gene expression profiles of tumours. Genomic fingerprints may refine prediction of the course of disease and response to adjuvant interventions. This review will focus on the role of multiparameter gene expression analyses in early breast cancer, with regards to prognosis and prediction. The prognostic role of genomic signatures, particularly the Mammaprint and Rotterdam signatures, is evolving. With regard to prediction of outcome, the Oncotype Dx multigene assay is in clinical use in tamoxifen treated patients. Extensive research continues on predictive gene identification for specific chemotherapeutic agents, particularly the anthracyclines, taxanes and alkylating agents.}, author = {Oakman, Catherine and Bessi, Silvia and Zafarana, Elena and Galardi, Francesca and Biganzoli, Laura and Di Leo, Angelo}, citeulike-article-id = {4272196}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/bcr2238}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19435470}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19435470}, day = {03}, doi = {10.1186/bcr2238}, issn = {1465-5411}, journal = {Breast Cancer Research}, keywords = {biomarkers, breast\_cancer, gene\_expression, review}, month = {April}, number = {2}, pages = {205+}, posted-at = {2009-11-08 22:48:04}, priority = {2}, title = {Recent advances in systemic therapy. New diagnostics and biological predictors of outcome in early breast cancer}, url = {http://dx.doi.org/10.1186/bcr2238}, volume = {11}, year = {2009} }

TY - JOUR ID - citeulike:4272196 L3 - citeulike-article-id:4272196 N2 - The key to optimising our approach in early breast cancer is to individualise care. Each patient has a tumour with innate features that dictate their chance of relapse and their responsiveness to treatment. Often patients with similar clinical and pathological tumours will have markedly different outcomes and responses to adjuvant intervention. These differences are encoded in the tumour genetic profile. Effective biomarkers may replace or complement traditional clinical and histopathological markers in assessing tumour behaviour and risk. Development of high-throughput genomic technologies is enabling the study of gene expression profiles of tumours. Genomic fingerprints may refine prediction of the course of disease and response to adjuvant interventions. This review will focus on the role of multiparameter gene expression analyses in early breast cancer, with regards to prognosis and prediction. The prognostic role of genomic signatures, particularly the Mammaprint and Rotterdam signatures, is evolving. With regard to prediction of outcome, the Oncotype Dx multigene assay is in clinical use in tamoxifen treated patients. Extensive research continues on predictive gene identification for specific chemotherapeutic agents, particularly the anthracyclines, taxanes and alkylating agents. IS - 2 JF - Breast Cancer Research SN - 1465-5411 TI - Recent advances in systemic therapy. New diagnostics and biological predictors of outcome in early breast cancer VL - 11 SP - 205 KW - biomarkers KW - breast_cancer KW - gene_expression KW - review AU - Oakman, Catherine AU - Bessi, Silvia AU - Zafarana, Elena AU - Galardi, Francesca AU - Biganzoli, Laura AU - Di Leo, Angelo PY - 2009/04/03/ UR - http://dx.doi.org/10.1186/bcr2238 ER -