Identification of deletion mutations and three new genes at the familial polyposis locus. Export

@article{citeulike:4369123, abstract = {Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in polyposis 1), was found to be transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, that is transcribed in the same orientation as SRP19.}, author = {Joslyn, G. and Carlson, M. and Thliveris, A. and Albertsen, H. and Gelbert, L. and Samowitz, W. and Groden, J. and Stevens, J. and Spirio, L. and Robertson, M.}, citeulike-article-id = {4369123}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/1678319}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=1678319}, day = {9}, issn = {0092-8674}, journal = {Cell}, keywords = {apc, crc\_bib}, month = {August}, number = {3}, pages = {601--613}, posted-at = {2009-04-20 14:50:58}, priority = {1}, title = {Identification of deletion mutations and three new genes at the familial polyposis locus.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/1678319}, volume = {66}, year = {1991} }

TY - JOUR ID - citeulike:4369123 L3 - citeulike-article-id:4369123 N2 - Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in polyposis 1), was found to be transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, that is transcribed in the same orientation as SRP19. IS - 3 JF - Cell SN - 0092-8674 EP - 613 TI - Identification of deletion mutations and three new genes at the familial polyposis locus. VL - 66 SP - 601 KW - apc KW - crc_bib AU - Joslyn, G AU - Carlson, M AU - Thliveris, A AU - Albertsen, H AU - Gelbert, L AU - Samowitz, W AU - Groden, J AU - Stevens, J AU - Spirio, L AU - Robertson, M PY - 1991/08/09/ UR - http://view.ncbi.nlm.nih.gov/pubmed/1678319 ER -