Effect of providing a formula supplemented with long-chain polyunsaturated fatty acids on immunity in full-term neonates. Export

@article{citeulike:2727409, abstract = {To determine the effect of feeding formula containing long-chain PUFA (LCP) on immune function, healthy term infants were randomised at age 2 weeks to either a standard term formula (Formula; n 14) or the same formula supplemented with the LCP 20 : 4n-6 and 22 : 6n-3 (Formula+LCP; n 16). Peripheral blood was collected at 2 and 6 weeks to measure immune cell response (the rate of [3H]thymidine uptake and cytokine production after stimulation with phytohaemagglutinin (PHA)). Compared with cells from infants receiving only human milk (HM), the rate of [3H]thymidine uptake in response to PHA, but not IL-2 production, was lower for Formula+LCP infants (P < 0.05). Compared with HM-fed infants, Formula-fed infants (but not Formula+LCP infants) produced more TNF-alpha (unstimulated) and had a fewer CD3+CD44+ cells before stimulation and fewer CD11c+ cells post-stimulation (P < 0.05). However, compared with Formula-fed infants, the Formula+LCP infants had an immune cell distribution (higher percentage CD3+CD44+ and CD4+CD28+ cells) and cytokine profile (lower production of TNF-alpha post-stimulation) that did not differ from HM infants. Additionally, it was found that feeding infants formula during the first 10 d of life influenced immune function. These infants had a higher percentage of CD3+, CD4+CD28+, and lower percentage of CD14+ cells and produced more TNF-alpha and interferon-gamma after PHA stimulation than HM-fed infants (P < 0.05). These results demonstrate that early diet influences both the presence of specific cell types and function of infant blood immune cells. Since many diseases have a strong immunological component, these immune changes may be of physiological importance to the developing infant.}, address = {Nutrition and Metabolism Research Group, University of Alberta, Edmonton, Alberta T6G 2P5, Canada. Catherine.field@ualberta.ca}, author = {Field, C. J. and Van Aerde, J. E. and Robinson, L. E. and Clandinin, M. T.}, citeulike-article-id = {2727409}, citeulike-linkout-0 = {http://dx.doi.org/10.1017/S0007114507791845}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17640422}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17640422}, doi = {10.1017/S0007114507791845}, issn = {0007-1145}, journal = {The British journal of nutrition}, keywords = {formula}, month = {January}, number = {1}, pages = {91--99}, posted-at = {2008-04-28 07:09:31}, priority = {2}, title = {Effect of providing a formula supplemented with long-chain polyunsaturated fatty acids on immunity in full-term neonates.}, url = {http://dx.doi.org/10.1017/S0007114507791845}, volume = {99}, year = {2008} }

TY - JOUR ID - citeulike:2727409 L3 - citeulike-article-id:2727409 N2 - To determine the effect of feeding formula containing long-chain PUFA (LCP) on immune function, healthy term infants were randomised at age 2 weeks to either a standard term formula (Formula; n 14) or the same formula supplemented with the LCP 20 : 4n-6 and 22 : 6n-3 (Formula+LCP; n 16). Peripheral blood was collected at 2 and 6 weeks to measure immune cell response (the rate of [3H]thymidine uptake and cytokine production after stimulation with phytohaemagglutinin (PHA)). Compared with cells from infants receiving only human milk (HM), the rate of [3H]thymidine uptake in response to PHA, but not IL-2 production, was lower for Formula+LCP infants (P < 0.05). Compared with HM-fed infants, Formula-fed infants (but not Formula+LCP infants) produced more TNF-alpha (unstimulated) and had a fewer CD3+CD44+ cells before stimulation and fewer CD11c+ cells post-stimulation (P < 0.05). However, compared with Formula-fed infants, the Formula+LCP infants had an immune cell distribution (higher percentage CD3+CD44+ and CD4+CD28+ cells) and cytokine profile (lower production of TNF-alpha post-stimulation) that did not differ from HM infants. Additionally, it was found that feeding infants formula during the first 10 d of life influenced immune function. These infants had a higher percentage of CD3+, CD4+CD28+, and lower percentage of CD14+ cells and produced more TNF-alpha and interferon-gamma after PHA stimulation than HM-fed infants (P < 0.05). These results demonstrate that early diet influences both the presence of specific cell types and function of infant blood immune cells. Since many diseases have a strong immunological component, these immune changes may be of physiological importance to the developing infant. IS - 1 JF - The British journal of nutrition SN - 0007-1145 AD - Nutrition and Metabolism Research Group, University of Alberta, Edmonton, Alberta T6G 2P5, Canada. Catherine.field@ualberta.ca EP - 99 TI - Effect of providing a formula supplemented with long-chain polyunsaturated fatty acids on immunity in full-term neonates. VL - 99 SP - 91 KW - formula AU - Field, CJ AU - Van Aerde, JE AU - Robinson, LE AU - Clandinin, MT PY - 2008/01// UR - http://dx.doi.org/10.1017/S0007114507791845 ER -