A network of protein-protein interactions in yeast. Export

@article{citeulike:1293006, abstract = {A global analysis of 2,709 published interactions between proteins of the yeast Saccharomyces cerevisiae has been performed, enabling the establishment of a single large network of 2,358 interactions among 1,548 proteins. Proteins of known function and cellular location tend to cluster together, with 63\% of the interactions occurring between proteins with a common functional assignment and 76\% occurring between proteins found in the same subcellular compartment. Possible functions can be assigned to a protein based on the known functions of its interacting partners. This approach correctly predicts a functional category for 72\% of the 1,393 characterized proteins with at least one partner of known function, and has been applied to predict functions for 364 previously uncharacterized proteins.}, address = {The Institute for Systems Biology, 4225 Roosevelt Way NE, Suite 200, Seattle, WA 98105, USA.}, author = {Schwikowski, B. and Uetz, P. and Fields, S.}, citeulike-article-id = {1293006}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/82360}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nbt1200_1257}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/11101803}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=11101803}, doi = {10.1038/82360}, issn = {1087-0156}, journal = {Nat Biotechnol}, keywords = {function\_prediction}, month = {December}, number = {12}, pages = {1257--1261}, posted-at = {2008-03-19 20:57:26}, priority = {2}, title = {A network of protein-protein interactions in yeast.}, url = {http://dx.doi.org/10.1038/82360}, volume = {18}, year = {2000} }

TY - JOUR ID - citeulike:1293006 L3 - citeulike-article-id:1293006 N2 - A global analysis of 2,709 published interactions between proteins of the yeast Saccharomyces cerevisiae has been performed, enabling the establishment of a single large network of 2,358 interactions among 1,548 proteins. Proteins of known function and cellular location tend to cluster together, with 63% of the interactions occurring between proteins with a common functional assignment and 76% occurring between proteins found in the same subcellular compartment. Possible functions can be assigned to a protein based on the known functions of its interacting partners. This approach correctly predicts a functional category for 72% of the 1,393 characterized proteins with at least one partner of known function, and has been applied to predict functions for 364 previously uncharacterized proteins. IS - 12 JF - Nat Biotechnol SN - 1087-0156 AD - The Institute for Systems Biology, 4225 Roosevelt Way NE, Suite 200, Seattle, WA 98105, USA. EP - 1261 TI - A network of protein-protein interactions in yeast. VL - 18 SP - 1257 KW - function_prediction AU - Schwikowski, B AU - Uetz, P AU - Fields, S PY - 2000/12// UR - http://dx.doi.org/10.1038/82360 ER -