Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes. Export

@article{citeulike:2065282, abstract = {ABSTRACT : We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability of diverse phenotypes, spanning cellular morphology, growth, metabolism, and quantitative cell shape features. We apply the method to extend a genome-wide screen by predicting, then verifying, genes whose disruption elongates yeast cells, and to predict human disease genes. To facilitate network-guided screens, a web server is available http://www.yeastnet.org.}, author = {McGary, Kriston L. and Lee, Insuk and Marcotte, Edward M.}, citeulike-article-id = {2065282}, citeulike-linkout-0 = {http://dx.doi.org/10.1186/gb-2007-8-12-r258}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18053250}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18053250}, doi = {10.1186/gb-2007-8-12-r258}, issn = {1465-6914}, journal = {Genome biology}, keywords = {phen}, number = {12}, posted-at = {2008-09-08 04:56:55}, priority = {2}, title = {Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes.}, url = {http://dx.doi.org/10.1186/gb-2007-8-12-r258}, volume = {8}, year = {2007} }

TY - JOUR ID - citeulike:2065282 L3 - citeulike-article-id:2065282 N2 - ABSTRACT : We demonstrate that loss-of-function yeast phenotypes are predictable by guilt-by-association in functional gene networks. Testing 1,102 loss-of-function phenotypes from genome-wide assays of yeast reveals predictability of diverse phenotypes, spanning cellular morphology, growth, metabolism, and quantitative cell shape features. We apply the method to extend a genome-wide screen by predicting, then verifying, genes whose disruption elongates yeast cells, and to predict human disease genes. To facilitate network-guided screens, a web server is available http://www.yeastnet.org. IS - 12 JF - Genome biology SN - 1465-6914 TI - Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes. VL - 8 KW - phen AU - McGary, Kriston AU - Lee, Insuk AU - Marcotte, Edward PY - 2007/// UR - http://dx.doi.org/10.1186/gb-2007-8-12-r258 ER -