Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis. Export

@article{citeulike:1531036, abstract = {Inflammatory cells migrate to the lungs in response to Mycobacterium tuberculosis infection. These infiltrating cells organize into a structure called a granuloma, which controls and contains infection. The signals that influence the formation of granulomas are largely unknown. Tumor necrosis factor (TNF) has been demonstrated to be required for formation of granulomas, in mouse models of tuberculosis, and for control of latent tuberculosis, in humans. We investigated the mechanisms by which TNF controls cell migration in response to M. tuberculosis infection, focusing on the effects of this cytokine on chemokine expression. Chemokines are small molecules that direct the migration of cells within the body. Our data support the notion that TNF is required for appropriate chemokine expression by M. tuberculosis-infected macrophages, both in vitro and in vivo.}, address = {Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA.}, author = {Algood, H. M. and Lin, P. L. and Flynn, J. L.}, citeulike-article-id = {1531036}, citeulike-linkout-0 = {http://dx.doi.org/10.1086/429994}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15983898}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15983898}, day = {1}, doi = {10.1086/429994}, issn = {1537-6591}, journal = {Clin Infect Dis}, keywords = {chemokine, granuloma, mycobacterium\_tuberculosis, tnf}, month = {August}, posted-at = {2007-08-02 18:22:12}, priority = {0}, title = {Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis.}, url = {http://dx.doi.org/10.1086/429994}, volume = {41 Suppl 3}, year = {2005} }

TY - JOUR ID - citeulike:1531036 L3 - citeulike-article-id:1531036 N2 - Inflammatory cells migrate to the lungs in response to Mycobacterium tuberculosis infection. These infiltrating cells organize into a structure called a granuloma, which controls and contains infection. The signals that influence the formation of granulomas are largely unknown. Tumor necrosis factor (TNF) has been demonstrated to be required for formation of granulomas, in mouse models of tuberculosis, and for control of latent tuberculosis, in humans. We investigated the mechanisms by which TNF controls cell migration in response to M. tuberculosis infection, focusing on the effects of this cytokine on chemokine expression. Chemokines are small molecules that direct the migration of cells within the body. Our data support the notion that TNF is required for appropriate chemokine expression by M. tuberculosis-infected macrophages, both in vitro and in vivo. JF - Clin Infect Dis SN - 1537-6591 AD - Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA. TI - Tumor necrosis factor and chemokine interactions in the formation and maintenance of granulomas in tuberculosis. VL - 41 Suppl 3 KW - chemokine KW - granuloma KW - mycobacterium_tuberculosis KW - tnf AU - Algood, HM AU - Lin, PL AU - Flynn, JL PY - 2005/08/01/ UR - http://dx.doi.org/10.1086/429994 ER -