Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signaling chemokines. Export

@article{citeulike:1838402, abstract = {Among the first cells to invade a site of infection, polymorphonuclear neutrophils (PMN) play an important role in the control of numerous infections. While PMN are considered critical for control of acute infections, their role in chronic infections remains less well understood. Here we report that PMN are essential for accurate early granuloma formation during chronic M. tuberculosis infection without influencing mycobacterial growth restriction. The PMN-mediated regulation of granuloma formation depended on chemokines signaling through CXCR3, in particular MIG, as indicated by immune histochemical analysis of lung sections from C57BL/6 wild-type and CXCR3(-/-) mutant mice and supported by microarray transcriptome analysis. Hence, PMN play a central role in regulating the focal granulomatous response in the lung, and this early granuloma formation can be segregated from long-term protection against pulmonary M. tuberculosis infection.}, address = {Max-Planck-Institute for Infection Biology, Department of Immunology, Berlin, Germany. seler@mpiib-berlin.mpg.de}, author = {Seiler, P. and Aichele, P. and Bandermann, S. and Hauser, A. E. and Lu, B. and Gerard, N. P. and Gerard, C. and Ehlers, S. and Mollenkopf, H. J. and Kaufmann, S. H.}, citeulike-article-id = {1838402}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/eji.200323956}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/14515251}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=14515251}, doi = {10.1002/eji.200323956}, issn = {0014-2980}, journal = {Eur J Immunol}, keywords = {chemokine, neutrophil}, month = {October}, number = {10}, pages = {2676--2686}, posted-at = {2007-10-30 02:30:46}, priority = {0}, title = {Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signaling chemokines.}, url = {http://dx.doi.org/10.1002/eji.200323956}, volume = {33}, year = {2003} }

TY - JOUR ID - citeulike:1838402 L3 - citeulike-article-id:1838402 N2 - Among the first cells to invade a site of infection, polymorphonuclear neutrophils (PMN) play an important role in the control of numerous infections. While PMN are considered critical for control of acute infections, their role in chronic infections remains less well understood. Here we report that PMN are essential for accurate early granuloma formation during chronic M. tuberculosis infection without influencing mycobacterial growth restriction. The PMN-mediated regulation of granuloma formation depended on chemokines signaling through CXCR3, in particular MIG, as indicated by immune histochemical analysis of lung sections from C57BL/6 wild-type and CXCR3(-/-) mutant mice and supported by microarray transcriptome analysis. Hence, PMN play a central role in regulating the focal granulomatous response in the lung, and this early granuloma formation can be segregated from long-term protection against pulmonary M. tuberculosis infection. IS - 10 JF - Eur J Immunol SN - 0014-2980 AD - Max-Planck-Institute for Infection Biology, Department of Immunology, Berlin, Germany. seler@mpiib-berlin.mpg.de EP - 2686 TI - Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signaling chemokines. VL - 33 SP - 2676 KW - chemokine KW - neutrophil AU - Seiler, P AU - Aichele, P AU - Bandermann, S AU - Hauser, AE AU - Lu, B AU - Gerard, NP AU - Gerard, C AU - Ehlers, S AU - Mollenkopf, HJ AU - Kaufmann, SH PY - 2003/10// UR - http://dx.doi.org/10.1002/eji.200323956 ER -