Control, exploitation and tolerance of intracellular noise Export

@article{citeulike:306117, abstract = {Noise has many roles in biological function, including generation of errors in DNA replication leading to mutation and evolution, noise-driven divergence of cell fates, noise-induced amplification of signals, and maintenance of the quantitative individuality of cells. Yet there is order to the behaviour and development of cells. They operate within strict parameters and in many cases this behaviour seems robust, implying that noise is largely filtered by the system. How can we explain the use, rejection and sensitivity to noise that is found in biological systems? An exploration of the sources and consequences of noise calls for the use of stochastic models.}, author = {Rao, Christopher V. and Wolf, Denise M. and Arkin, Adam P.}, citeulike-article-id = {306117}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature01258}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature01258}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12432408}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12432408}, day = {14}, doi = {10.1038/nature01258}, issn = {0028-0836}, journal = {Nature}, keywords = {gene\_regulation, noise, stochastic}, month = {November}, number = {6912}, pages = {231--237}, posted-at = {2009-03-03 17:22:07}, priority = {2}, publisher = {Nature Publishing Group}, title = {Control, exploitation and tolerance of intracellular noise}, url = {http://dx.doi.org/10.1038/nature01258}, volume = {420}, year = {2002} }

TY - JOUR ID - citeulike:306117 L3 - citeulike-article-id:306117 N2 - Noise has many roles in biological function, including generation of errors in DNA replication leading to mutation and evolution, noise-driven divergence of cell fates, noise-induced amplification of signals, and maintenance of the quantitative individuality of cells. Yet there is order to the behaviour and development of cells. They operate within strict parameters and in many cases this behaviour seems robust, implying that noise is largely filtered by the system. How can we explain the use, rejection and sensitivity to noise that is found in biological systems? An exploration of the sources and consequences of noise calls for the use of stochastic models. IS - 6912 JF - Nature SN - 0028-0836 EP - 237 TI - Control, exploitation and tolerance of intracellular noise PB - Nature Publishing Group VL - 420 SP - 231 KW - gene_regulation KW - noise KW - stochastic AU - Rao, Christopher AU - Wolf, Denise AU - Arkin, Adam PY - 2002/11/14/ UR - http://dx.doi.org/10.1038/nature01258 ER -