Transcription factor function and promoter architecture govern the evolution of bacterial regulons Export

@article{citeulike:4119631, abstract = {10.1073/pnas.0810343106 Evolutionary changes in ancestral regulatory circuits can bring about phenotypic differences between related organisms. Studies of regulatory circuits in eukaryotes suggest that these modifications result primarily from changes in -regulatory elements (as opposed to alterations in the transcription factors that act upon these sequences). It is presently unclear how the evolution of gene regulatory circuits has proceeded in bacteria, given the rampant effects of horizontal gene transfer, which has significantly altered the composition of bacterial regulons. We now demonstrate that the evolution of the regulons governed by the regulatory protein PhoP in the related human pathogens and has entailed functional changes in the PhoP protein as well as in the architecture of PhoP-dependent promoters. These changes have resulted in orthologous PhoP proteins that differ both in their ability to promote transcription and in their role as virulence regulators. We posit that these changes allow bacterial transcription factors to incorporate newly acquired genes into ancestral regulatory circuits and yet retain control of the core members of a regulon.}, author = {Perez, Christian J. and Groisman, Eduardo A.}, citeulike-article-id = {4119631}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0810343106}, citeulike-linkout-1 = {http://www.pnas.org/content/0810343106v1//.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/0810343106v1//.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19251636}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19251636}, day = {27}, doi = {10.1073/pnas.0810343106}, journal = {Proceedings of the National Academy of Sciences}, keywords = {bacteria, evolution, gene\_regulation, phopq, regulon, transcription, two-component\_system}, month = {February}, posted-at = {2009-03-02 15:42:22}, priority = {0}, title = {Transcription factor function and promoter architecture govern the evolution of bacterial regulons}, url = {http://dx.doi.org/10.1073/pnas.0810343106}, year = {2009} }

TY - JOUR ID - citeulike:4119631 L3 - citeulike-article-id:4119631 N2 - 10.1073/pnas.0810343106 Evolutionary changes in ancestral regulatory circuits can bring about phenotypic differences between related organisms. Studies of regulatory circuits in eukaryotes suggest that these modifications result primarily from changes in -regulatory elements (as opposed to alterations in the transcription factors that act upon these sequences). It is presently unclear how the evolution of gene regulatory circuits has proceeded in bacteria, given the rampant effects of horizontal gene transfer, which has significantly altered the composition of bacterial regulons. We now demonstrate that the evolution of the regulons governed by the regulatory protein PhoP in the related human pathogens and has entailed functional changes in the PhoP protein as well as in the architecture of PhoP-dependent promoters. These changes have resulted in orthologous PhoP proteins that differ both in their ability to promote transcription and in their role as virulence regulators. We posit that these changes allow bacterial transcription factors to incorporate newly acquired genes into ancestral regulatory circuits and yet retain control of the core members of a regulon. JF - Proceedings of the National Academy of Sciences TI - Transcription factor function and promoter architecture govern the evolution of bacterial regulons KW - bacteria KW - evolution KW - gene_regulation KW - phopq KW - regulon KW - transcription KW - two-component_system AU - Perez, Christian AU - Groisman, Eduardo PY - 2009/02/27/ UR - http://dx.doi.org/10.1073/pnas.0810343106 ER -