Waddington's canalization revisited: developmental stability and evolution. Export

@article{citeulike:445636, abstract = {Most species maintain abundant genetic variation and experience a range of environmental conditions, yet phenotypic variation is low. That is, development is robust to changes in genotype and environment. It has been claimed that this robustness, termed canalization, evolves because of long-term natural selection for optimal phenotypes. We show that the developmental process, here modeled as a network of interacting transcriptional regulators, constrains the genetic system to produce canalization, even without selection toward an optimum. The extent of canalization, measured as the insensitivity to mutation of a network's equilibrium state, depends on the complexity of the network, such that more highly connected networks evolve to be more canalized. We argue that canalization may be an inevitable consequence of complex developmental-genetic processes and thus requires no explanation in terms of evolution to suppress phenotypic variation.}, address = {Department of Biological Sciences, and Center for Computational Genetics and Biological Modeling, Stanford University, Stanford, CA 94305-5020, USA.}, author = {Siegal, Mark L. and Bergman, Aviv}, citeulike-article-id = {445636}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.102303999}, citeulike-linkout-1 = {http://www.pnas.org/content/99/16/10528.abstract}, citeulike-linkout-2 = {http://www.pnas.org/content/99/16/10528.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/12082173}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=12082173}, day = {6}, doi = {10.1073/pnas.102303999}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America. }, keywords = {canalization, complexity, development, evolution, network, stability}, month = {August}, number = {16}, pages = {10528--10532}, posted-at = {2009-06-04 23:11:52}, priority = {2}, title = {Waddington's canalization revisited: developmental stability and evolution.}, url = {http://dx.doi.org/10.1073/pnas.102303999}, volume = {99}, year = {2002} }

TY - JOUR ID - citeulike:445636 L3 - citeulike-article-id:445636 N2 - Most species maintain abundant genetic variation and experience a range of environmental conditions, yet phenotypic variation is low. That is, development is robust to changes in genotype and environment. It has been claimed that this robustness, termed canalization, evolves because of long-term natural selection for optimal phenotypes. We show that the developmental process, here modeled as a network of interacting transcriptional regulators, constrains the genetic system to produce canalization, even without selection toward an optimum. The extent of canalization, measured as the insensitivity to mutation of a network's equilibrium state, depends on the complexity of the network, such that more highly connected networks evolve to be more canalized. We argue that canalization may be an inevitable consequence of complex developmental-genetic processes and thus requires no explanation in terms of evolution to suppress phenotypic variation. IS - 16 JF - Proceedings of the National Academy of Sciences of the United States of America. SN - 0027-8424 AD - Department of Biological Sciences, and Center for Computational Genetics and Biological Modeling, Stanford University, Stanford, CA 94305-5020, USA. EP - 10532 TI - Waddington's canalization revisited: developmental stability and evolution. VL - 99 SP - 10528 KW - canalization KW - complexity KW - development KW - evolution KW - network KW - stability AU - Siegal, Mark AU - Bergman, Aviv PY - 2002/08/06/ UR - http://dx.doi.org/10.1073/pnas.102303999 ER -