Positive selection for elevated gene expression noise in yeast. Export

@article{citeulike:5487063, abstract = {It is well known that the expression noise is lessened by natural selection for genes that are important for cell growth or are sensitive to dosage. In theory, expression noise can also be elevated by natural selection when noisy gene expression is advantageous. Here we analyze yeast genome-wide gene expression noise data and show that plasma-membrane transporters show significantly elevated expression noise after controlling all confounding factors. We propose a model that explains why and under what conditions elevated expression noise may be beneficial and subject to positive selection. Our model predicts and the simulation confirms that, under certain conditions, expression noise also increases the evolvability of gene expression by promoting the fixation of favorable expression level-altering mutations. Indeed, yeast genes with higher noise show greater between-strain and between-species divergences in expression, even when all confounding factors are excluded. Together, our theoretical model and empirical results suggest that, for yeast genes such as plasma-membrane transporters, elevated expression noise is advantageous, is subject to positive selection, and is a facilitator of adaptive gene expression evolution.}, author = {Zhang, Zhihua and Qian, Wenfeng and Zhang, Jianzhi}, citeulike-article-id = {5487063}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/msb.2009.58}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/msb200958}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19690568}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19690568}, day = {18}, doi = {10.1038/msb.2009.58}, issn = {1744-4292}, journal = {Molecular systems biology}, keywords = {evolution, gene\_expression, noise, yeast}, month = {August}, posted-at = {2009-08-19 16:53:33}, priority = {0}, publisher = {EMBO and Nature Publishing Group}, title = {Positive selection for elevated gene expression noise in yeast.}, url = {http://dx.doi.org/10.1038/msb.2009.58}, volume = {5}, year = {2009} }

TY - JOUR ID - citeulike:5487063 L3 - citeulike-article-id:5487063 N2 - It is well known that the expression noise is lessened by natural selection for genes that are important for cell growth or are sensitive to dosage. In theory, expression noise can also be elevated by natural selection when noisy gene expression is advantageous. Here we analyze yeast genome-wide gene expression noise data and show that plasma-membrane transporters show significantly elevated expression noise after controlling all confounding factors. We propose a model that explains why and under what conditions elevated expression noise may be beneficial and subject to positive selection. Our model predicts and the simulation confirms that, under certain conditions, expression noise also increases the evolvability of gene expression by promoting the fixation of favorable expression level-altering mutations. Indeed, yeast genes with higher noise show greater between-strain and between-species divergences in expression, even when all confounding factors are excluded. Together, our theoretical model and empirical results suggest that, for yeast genes such as plasma-membrane transporters, elevated expression noise is advantageous, is subject to positive selection, and is a facilitator of adaptive gene expression evolution. JF - Molecular systems biology SN - 1744-4292 TI - Positive selection for elevated gene expression noise in yeast. PB - EMBO and Nature Publishing Group VL - 5 KW - evolution KW - gene_expression KW - noise KW - yeast AU - Zhang, Zhihua AU - Qian, Wenfeng AU - Zhang, Jianzhi PY - 2009/08/18/ UR - http://dx.doi.org/10.1038/msb.2009.58 ER -