Maximum likelihood and the single receptor Export

@article{citeulike:5847570, abstract = {Biological cells are able to accurately sense chemicals with receptors at their surfaces, allowing cells to move towards sources of attractant and away from sources of repellent. The accuracy of sensing chemical concentration is ultimately limited by the random arrival of particles at the receptors by diffusion. This fundamental physical limit is generally considered to be the Berg \& Purcell limit [H.C. Berg and E.M. Purcell, Biophys. J. {\bf 20}, 193 (1977)]. Here we derive a lower limit by applying maximum likelihood to the time series of receptor occupancy. The increased accuracy stems from solely considering the unoccupied time intervals - disregarding the occupied time intervals as these do not contain any information about the external particle concentration, and only decrease the accuracy of the concentration estimate. Receptors which minimize the bound time intervals achieve the highest possible accuracy. We discuss how a cell could implement such an optimal sensing strategy by absorbing or degrading bound particles.}, archivePrefix = {arXiv}, author = {Endres, Robert G. and Wingreen, Ned S.}, citeulike-article-id = {5847570}, citeulike-linkout-0 = {http://arxiv.org/abs/0909.4710}, citeulike-linkout-1 = {http://arxiv.org/pdf/0909.4710}, day = {25}, eprint = {0909.4710}, keywords = {bacteria, chemotaxis, physical\_limit, receptor, signaling}, month = {Sep}, posted-at = {2009-09-28 20:13:34}, priority = {2}, title = {Maximum likelihood and the single receptor}, url = {http://arxiv.org/abs/0909.4710}, year = {2009} }

TY - JOUR ID - citeulike:5847570 L3 - citeulike-article-id:5847570 N2 - Biological cells are able to accurately sense chemicals with receptors at their surfaces, allowing cells to move towards sources of attractant and away from sources of repellent. The accuracy of sensing chemical concentration is ultimately limited by the random arrival of particles at the receptors by diffusion. This fundamental physical limit is generally considered to be the Berg & Purcell limit [H.C. Berg and E.M. Purcell, Biophys. J. {\bf 20}, 193 (1977)]. Here we derive a lower limit by applying maximum likelihood to the time series of receptor occupancy. The increased accuracy stems from solely considering the unoccupied time intervals - disregarding the occupied time intervals as these do not contain any information about the external particle concentration, and only decrease the accuracy of the concentration estimate. Receptors which minimize the bound time intervals achieve the highest possible accuracy. We discuss how a cell could implement such an optimal sensing strategy by absorbing or degrading bound particles. TI - Maximum likelihood and the single receptor KW - bacteria KW - chemotaxis KW - physical_limit KW - receptor KW - signaling AU - Endres, Robert AU - Wingreen, Ned PY - 2009/Sep/25/ UR - http://arxiv.org/abs/0909.4710 ER -