Coexistence of Flexibility and Stability of Proteins: An Equation of State Export

@article{citeulike:5944524, abstract = {We consider a recently suggested ” equation of state” for natively folded proteins, and verify its validity for a set of about 5800 proteins. The equation is based on a fractal viewpoint of proteins, on a generalization of the Landau-Peierls instability, and on a marginal stability criterion. The latter allows for coexistence of stability and flexibility of proteins, which is required for their proper function. The equation of state relates the protein fractal dimension , its spectral dimension , and the number of amino acids N . Using structural data from the protein data bank (PDB) and the Gaussian network model (GNM), we compute and for the entire set and demonstrate that the equation of state is well obeyed. Addressing the fractal properties and making use of the equation of state may help to engineer biologically inspired catalysts.}, author = {de Leeuw, Marina and Reuveni, Shlomi and Klafter, Joseph and Granek, Rony}, citeulike-article-id = {5944524}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pone.0007296}, day = {9}, doi = {10.1371/journal.pone.0007296}, journal = {PLoS ONE}, keywords = {flexibility, mathematical\_model, protein\_folding, stability}, month = {October}, number = {10}, pages = {e7296+}, posted-at = {2009-10-15 16:44:14}, priority = {2}, publisher = {Public Library of Science}, title = {Coexistence of Flexibility and Stability of Proteins: An Equation of State}, url = {http://dx.doi.org/10.1371/journal.pone.0007296}, volume = {4}, year = {2009} }

TY - JOUR ID - citeulike:5944524 L3 - citeulike-article-id:5944524 N2 - We consider a recently suggested “equation of state” for natively folded proteins, and verify its validity for a set of about 5800 proteins. The equation is based on a fractal viewpoint of proteins, on a generalization of the Landau-Peierls instability, and on a marginal stability criterion. The latter allows for coexistence of stability and flexibility of proteins, which is required for their proper function. The equation of state relates the protein fractal dimension , its spectral dimension , and the number of amino acids N . Using structural data from the protein data bank (PDB) and the Gaussian network model (GNM), we compute and for the entire set and demonstrate that the equation of state is well obeyed. Addressing the fractal properties and making use of the equation of state may help to engineer biologically inspired catalysts. IS - 10 JF - PLoS ONE TI - Coexistence of Flexibility and Stability of Proteins: An Equation of State PB - Public Library of Science VL - 4 SP - e7296 KW - flexibility KW - mathematical_model KW - protein_folding KW - stability AU - de Leeuw, Marina AU - Reuveni, Shlomi AU - Klafter, Joseph AU - Granek, Rony PY - 2009/10/09/ UR - http://dx.doi.org/10.1371/journal.pone.0007296 ER -