Bicuculline enhances a negative component and diminishes a positive component of the visual evoked cortical potential in the cat. Export

@article{citeulike:4490988, abstract = {Visual evoked potentials (VEPs), elicited by modulation of luminance of homogeneous fields of light, were recorded from the scalp and from the surface of the visual cortex of cats before and after topical application of bicuculline to the cortex. The application of this drug drastically altered the VEP: the amplitude of a normally small negative component was increased greatly, and a normally prominent late positive component was diminished. Bicuculline is known to block the action of gamma-aminobutyric acid, which is thought to be the primary inhibitory neurotransmitter in the visual cortex. We suggest, therefore, that the affected negative wave reflects an excitatory process in the visual cortex and that the affected late positive wave reflects an intracortical inhibitory process.}, author = {Zemon, V. and Kaplan, E. and Ratliff, F.}, citeulike-article-id = {4490988}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/6938987}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=6938987}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {bicuculline, eeg, gaba, vep}, month = {December}, number = {12}, pages = {7476--7478}, posted-at = {2009-05-08 04:10:42}, priority = {3}, title = {Bicuculline enhances a negative component and diminishes a positive component of the visual evoked cortical potential in the cat.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/6938987}, volume = {77}, year = {1980} }

TY - JOUR ID - citeulike:4490988 L3 - citeulike-article-id:4490988 N2 - Visual evoked potentials (VEPs), elicited by modulation of luminance of homogeneous fields of light, were recorded from the scalp and from the surface of the visual cortex of cats before and after topical application of bicuculline to the cortex. The application of this drug drastically altered the VEP: the amplitude of a normally small negative component was increased greatly, and a normally prominent late positive component was diminished. Bicuculline is known to block the action of gamma-aminobutyric acid, which is thought to be the primary inhibitory neurotransmitter in the visual cortex. We suggest, therefore, that the affected negative wave reflects an excitatory process in the visual cortex and that the affected late positive wave reflects an intracortical inhibitory process. IS - 12 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 EP - 7478 TI - Bicuculline enhances a negative component and diminishes a positive component of the visual evoked cortical potential in the cat. VL - 77 SP - 7476 KW - bicuculline KW - eeg KW - gaba KW - vep AU - Zemon, V AU - Kaplan, E AU - Ratliff, F PY - 1980/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/6938987 ER -