Dysfunction of early-stage visual processing in schizophrenia. Export

@article{citeulike:4569696, abstract = {OBJECTIVE: Schizophrenia is associated with deficits in higher-order processing of visual information. This study evaluated the integrity of early visual processing in order to evaluate the overall pattern of visual dysfunction in schizophrenia. METHOD: Steady-state visual-evoked potential responses were recorded over the occipital cortex in patients with schizophrenia and in age- and sex-matched comparison volunteers. Visual-evoked potentials were obtained for stimuli composed of isolated squares that were modulated sinusoidally in luminance contrast, number of squares, or chromatic contrast in order to emphasize magnocellular or parvocellular visual pathway activity. RESULTS: Responses of patients to magnocellular-biased stimuli were significantly lower than those of comparison volunteers. These lower response levels were observed in conditions using both low luminance contrast and large squares that biased processing toward the magnocellular pathway. In contrast, responses to stimuli that biased processing toward the parvocellular pathway were not significantly different between schizophrenia patients and comparison volunteers. A significant interaction of group and stimulus type was observed in the condition using low luminance contrast. CONCLUSIONS: These findings suggest a dysfunction of lower-level visual pathways, which was more prominent for magnocellular than parvocellular biased stimuli. The magnocellular pathway helps in orienting toward salient stimuli. A magnocellular pathway deficit could contribute to higher-level visual cognitive deficits in schizophrenia.}, author = {Butler, P. D. and Schechter, I. and Zemon, V. and Schwartz, S. G. and Greenstein, V. C. and Gordon, J. and Schroeder, C. E. and Javitt, D. C.}, citeulike-article-id = {4569696}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/11431235}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=11431235}, issn = {0002-953X}, journal = {The American Journal of Psychiatry}, keywords = {eeg, magnocellular, parvocellular, schizophrenia, ssvep}, month = {July}, number = {7}, pages = {1126--1133}, posted-at = {2009-05-21 14:41:58}, priority = {3}, title = {Dysfunction of early-stage visual processing in schizophrenia.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/11431235}, volume = {158}, year = {2001} }

TY - JOUR ID - citeulike:4569696 L3 - citeulike-article-id:4569696 N2 - OBJECTIVE: Schizophrenia is associated with deficits in higher-order processing of visual information. This study evaluated the integrity of early visual processing in order to evaluate the overall pattern of visual dysfunction in schizophrenia. METHOD: Steady-state visual-evoked potential responses were recorded over the occipital cortex in patients with schizophrenia and in age- and sex-matched comparison volunteers. Visual-evoked potentials were obtained for stimuli composed of isolated squares that were modulated sinusoidally in luminance contrast, number of squares, or chromatic contrast in order to emphasize magnocellular or parvocellular visual pathway activity. RESULTS: Responses of patients to magnocellular-biased stimuli were significantly lower than those of comparison volunteers. These lower response levels were observed in conditions using both low luminance contrast and large squares that biased processing toward the magnocellular pathway. In contrast, responses to stimuli that biased processing toward the parvocellular pathway were not significantly different between schizophrenia patients and comparison volunteers. A significant interaction of group and stimulus type was observed in the condition using low luminance contrast. CONCLUSIONS: These findings suggest a dysfunction of lower-level visual pathways, which was more prominent for magnocellular than parvocellular biased stimuli. The magnocellular pathway helps in orienting toward salient stimuli. A magnocellular pathway deficit could contribute to higher-level visual cognitive deficits in schizophrenia. IS - 7 JF - The American Journal of Psychiatry SN - 0002-953X EP - 1133 TI - Dysfunction of early-stage visual processing in schizophrenia. VL - 158 SP - 1126 KW - eeg KW - magnocellular KW - parvocellular KW - schizophrenia KW - ssvep AU - Butler, PD AU - Schechter, I AU - Zemon, V AU - Schwartz, SG AU - Greenstein, VC AU - Gordon, J AU - Schroeder, CE AU - Javitt, DC PY - 2001/07// UR - http://view.ncbi.nlm.nih.gov/pubmed/11431235 ER -