GABAergic dysfunction in mood disorders. Export

@article{citeulike:5241935, abstract = {The authors review the available literature on the preclinical and clinical studies involving GABAergic neurotransmission in mood disorders. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter present almost exclusively in the central nervous system (CNS), distributed across almost all brain regions, and expressed in interneurons modulating local circuits. The role of GABAergic dysfunction in mood disorders was first proposed 20 years ago. Preclinical studies have suggested that GABA levels may be decreased in animal models of depression, and clinical studies reported low plasma and CSF GABA levels in mood disorder patients. Also, antidepressants, mood stabilizers, electroconvulsive therapy, and GABA agonists have been shown to reverse the depression-like behavior in animal models and to be effective in unipolar and bipolar patients by increasing brain GABAergic activity. The hypothesis of reduced GABAergic activity in mood disorders may complement the monoaminergic and serotonergic theories, proposing that the balance between multiple neurotransmitter systems may be altered in these disorders. However, low GABAergic cortical function may probably be a feature of a subset of mood disorder patients, representing a genetic susceptibility. In this paper, we discuss the status of GABAergic hypothesis of mood disorders and suggest possible directions for future preclinical and clinical research in this area.}, author = {Brambilla, P. and Perez, J. and Barale, F. and Schettini, G. and Soares, J. C.}, citeulike-article-id = {5241935}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/sj.mp.4001362}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12888801}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12888801}, doi = {10.1038/sj.mp.4001362}, issn = {1359-4184}, journal = {Molecular Psychiatry}, keywords = {depression, gaba, review}, month = {August}, number = {8}, posted-at = {2009-07-23 21:07:57}, priority = {4}, title = {GABAergic dysfunction in mood disorders.}, url = {http://dx.doi.org/10.1038/sj.mp.4001362}, volume = {8}, year = {2003} }

TY - JOUR ID - citeulike:5241935 L3 - citeulike-article-id:5241935 N2 - The authors review the available literature on the preclinical and clinical studies involving GABAergic neurotransmission in mood disorders. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter present almost exclusively in the central nervous system (CNS), distributed across almost all brain regions, and expressed in interneurons modulating local circuits. The role of GABAergic dysfunction in mood disorders was first proposed 20 years ago. Preclinical studies have suggested that GABA levels may be decreased in animal models of depression, and clinical studies reported low plasma and CSF GABA levels in mood disorder patients. Also, antidepressants, mood stabilizers, electroconvulsive therapy, and GABA agonists have been shown to reverse the depression-like behavior in animal models and to be effective in unipolar and bipolar patients by increasing brain GABAergic activity. The hypothesis of reduced GABAergic activity in mood disorders may complement the monoaminergic and serotonergic theories, proposing that the balance between multiple neurotransmitter systems may be altered in these disorders. However, low GABAergic cortical function may probably be a feature of a subset of mood disorder patients, representing a genetic susceptibility. In this paper, we discuss the status of GABAergic hypothesis of mood disorders and suggest possible directions for future preclinical and clinical research in this area. IS - 8 JF - Molecular Psychiatry SN - 1359-4184 TI - GABAergic dysfunction in mood disorders. VL - 8 KW - depression KW - gaba KW - review AU - Brambilla, P AU - Perez, J AU - Barale, F AU - Schettini, G AU - Soares, JC PY - 2003/08// UR - http://dx.doi.org/10.1038/sj.mp.4001362 ER -