Large number of ultraconserved elements were already present in the jawed vertebrate ancestor. Export

@article{citeulike:3750145, abstract = {Stephen et al. (2008, 25: 402; doi:10.1093/molbev/msm268) identified 13,736 ultraconserved elements (UCEs) in placental mammals and investigated their evolution in opossum, chicken, frog and fugu. They found that there was a massive expansion of UCEs during tetrapod evolution and the substitution rate in UCEs showed a significant decline in tetrapods compared to fugu, suggesting they were exapted in tetrapods. They considered it unlikely that these elements are ancient but evolved at a higher rate in teleost fishes. In this study, we investigated the evolution of UCEs in a cartilaginous fish, the elephant shark and show that nearly half the UCEs were present in the jawed vertebrate ancestor. The substitution rate in UCEs is higher in fugu than in elephant shark, and approximately one-third of ancient UCEs have diverged beyond recognition in teleost fishes. These data indicate that UCEs have evolved at a higher rate in teleost fishes, which may have implications for their vast diversity and evolutionary success.}, author = {Wang, Jianli and Lee, Alison P P. and Kodzius, Rimantas and Brenner, Sydney and Venkatesh, Byrappa}, citeulike-article-id = {3750145}, citeulike-linkout-0 = {http://dx.doi.org/10.1093/molbev/msn278}, citeulike-linkout-1 = {http://mbe.oxfordjournals.org/cgi/content/abstract/26/3/487?etoc}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19052148}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19052148}, day = {3}, doi = {10.1093/molbev/msn278}, issn = {1537-1719}, journal = {Molecular biology and evolution}, keywords = {adaptation, evolution, tree-of-life, uce, vertebrate}, month = {December}, posted-at = {2009-02-16 16:32:31}, priority = {2}, title = {Large number of ultraconserved elements were already present in the jawed vertebrate ancestor.}, url = {http://dx.doi.org/10.1093/molbev/msn278}, year = {2008} }

TY - JOUR ID - citeulike:3750145 L3 - citeulike-article-id:3750145 N2 - Stephen et al. (2008, 25: 402; doi:10.1093/molbev/msm268) identified 13,736 ultraconserved elements (UCEs) in placental mammals and investigated their evolution in opossum, chicken, frog and fugu. They found that there was a massive expansion of UCEs during tetrapod evolution and the substitution rate in UCEs showed a significant decline in tetrapods compared to fugu, suggesting they were exapted in tetrapods. They considered it unlikely that these elements are ancient but evolved at a higher rate in teleost fishes. In this study, we investigated the evolution of UCEs in a cartilaginous fish, the elephant shark and show that nearly half the UCEs were present in the jawed vertebrate ancestor. The substitution rate in UCEs is higher in fugu than in elephant shark, and approximately one-third of ancient UCEs have diverged beyond recognition in teleost fishes. These data indicate that UCEs have evolved at a higher rate in teleost fishes, which may have implications for their vast diversity and evolutionary success. JF - Molecular biology and evolution SN - 1537-1719 TI - Large number of ultraconserved elements were already present in the jawed vertebrate ancestor. KW - adaptation KW - evolution KW - tree-of-life KW - uce KW - vertebrate AU - Wang, Jianli AU - Lee, Alison P AU - Kodzius, Rimantas AU - Brenner, Sydney AU - Venkatesh, Byrappa PY - 2008/12/03/ UR - http://dx.doi.org/10.1093/molbev/msn278 ER -