Fundamental concepts in genetics: Effective population size and patterns of molecular evolution and variation Export

@article{citeulike:4042290, abstract = {The effective size of a population, Ne, determines the rate of change in the composition of a population caused by genetic drift, which is the random sampling of genetic variants in a finite population. Ne is crucial in determining the level of variability in a population, and the effectiveness of selection relative to drift. This article reviews the properties of Ne in a variety of different situations of biological interest, and the factors that influence it. In particular, the action of selection means that Ne varies across the genome, and advances in genomic techniques are giving new insights into how selection shapes Ne.}, author = {Charlesworth, Brian}, citeulike-article-id = {4042290}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nrg2526}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nrg2526}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19204717}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19204717}, day = {01}, doi = {10.1038/nrg2526}, issn = {1471-0056}, journal = {Nature Reviews Genetics}, keywords = {effective-population-size, evolution, fundamental-concepts-in-genetics, genetic-drift, genetics, population-genetics}, month = {March}, number = {3}, pages = {195--205}, posted-at = {2009-03-05 17:58:52}, priority = {2}, publisher = {Nature Publishing Group}, title = {Fundamental concepts in genetics: Effective population size and patterns of molecular evolution and variation}, url = {http://dx.doi.org/10.1038/nrg2526}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:4042290 L3 - citeulike-article-id:4042290 N2 - The effective size of a population, Ne, determines the rate of change in the composition of a population caused by genetic drift, which is the random sampling of genetic variants in a finite population. Ne is crucial in determining the level of variability in a population, and the effectiveness of selection relative to drift. This article reviews the properties of Ne in a variety of different situations of biological interest, and the factors that influence it. In particular, the action of selection means that Ne varies across the genome, and advances in genomic techniques are giving new insights into how selection shapes Ne. IS - 3 JF - Nature Reviews Genetics SN - 1471-0056 EP - 205 TI - Fundamental concepts in genetics: Effective population size and patterns of molecular evolution and variation PB - Nature Publishing Group VL - 10 SP - 195 KW - effective-population-size KW - evolution KW - fundamental-concepts-in-genetics KW - genetic-drift KW - genetics KW - population-genetics AU - Charlesworth, Brian PY - 2009/03/01/ UR - http://dx.doi.org/10.1038/nrg2526 ER -