Bacterial Small-Molecule Signaling Pathways Export

@article{citeulike:519794, abstract = {Bacteria use diverse small molecules for extra- and intracellular signaling. They scan small-molecule mixtures to access information about both their extracellular environment and their intracellular physiological status, and based on this information, they continuously interpret their circumstances and react rapidly to changes. Bacteria must integrate extra- and intracellular signaling information to mount appropriate responses to changes in their environment. We review recent research into two fundamental bacterial small-molecule signaling pathways: extracellular quorum-sensing signaling and intracellular cyclic dinucleotide signaling. We suggest how these two pathways may converge to control complex processes including multicellularity, biofilm formation, and virulence. We also outline new questions that have arisen from recent studies in these fields.}, author = {Camilli, Andrew and Bassler, Bonnie L.}, citeulike-article-id = {519794}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1121357}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/311/5764/1113}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16497924}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16497924}, day = {24}, doi = {10.1126/science.1121357}, journal = {Science}, keywords = {bacteria, microorganism, quorum-sensing, signalling}, month = {February}, number = {5764}, pages = {1113--1116}, posted-at = {2006-07-27 16:58:41}, priority = {2}, title = {Bacterial Small-Molecule Signaling Pathways}, url = {http://dx.doi.org/10.1126/science.1121357}, volume = {311}, year = {2006} }

TY - JOUR ID - citeulike:519794 L3 - citeulike-article-id:519794 N2 - Bacteria use diverse small molecules for extra- and intracellular signaling. They scan small-molecule mixtures to access information about both their extracellular environment and their intracellular physiological status, and based on this information, they continuously interpret their circumstances and react rapidly to changes. Bacteria must integrate extra- and intracellular signaling information to mount appropriate responses to changes in their environment. We review recent research into two fundamental bacterial small-molecule signaling pathways: extracellular quorum-sensing signaling and intracellular cyclic dinucleotide signaling. We suggest how these two pathways may converge to control complex processes including multicellularity, biofilm formation, and virulence. We also outline new questions that have arisen from recent studies in these fields. IS - 5764 JF - Science EP - 1116 TI - Bacterial Small-Molecule Signaling Pathways VL - 311 SP - 1113 KW - bacteria KW - microorganism KW - quorum-sensing KW - signalling AU - Camilli, Andrew AU - Bassler, Bonnie PY - 2006/02/24/ UR - http://dx.doi.org/10.1126/science.1121357 ER -