A maximum likelihood approach to the detection of selection from a phylogeny Export

@article{golding90, abstract = {Summary A large amount of information is contained within the phylogentic relationships between species. In addition to their branching patterns it is also possible to examine other aspects of the biology of the species. The influence that deleterious selection might have is determined here. The likelihood of different phylogenies in the presence of selection is explored to determine the properties of such a likelihood surface. The calculation of likelihoods for a phylogeny in the presence and absence of selection, permits the application of a likelihood ratio test to search for selection. It is shown that even a single selected site can have a strong effect on the likelihood. The method is illustrated with an example fromDrosophila melanogaster and suggests that delerious selection may be acting on transposable elements.}, author = {Golding, Brian and Felsenstein, Joe}, citeulike-article-id = {5014214}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/BF02102078}, citeulike-linkout-1 = {http://www.springerlink.com/content/w310577563u54w3w}, day = {1}, doi = {10.1007/BF02102078}, journal = {Journal of Molecular Evolution}, month = {December}, number = {6}, pages = {511--523}, posted-at = {2009-06-29 17:31:39}, priority = {2}, title = {A maximum likelihood approach to the detection of selection from a phylogeny}, url = {http://dx.doi.org/10.1007/BF02102078}, volume = {31}, year = {1990} }

TY - JOUR ID - golding90 L3 - citeulike-article-id:5014214 N2 - Summary A large amount of information is contained within the phylogentic relationships between species. In addition to their branching patterns it is also possible to examine other aspects of the biology of the species. The influence that deleterious selection might have is determined here. The likelihood of different phylogenies in the presence of selection is explored to determine the properties of such a likelihood surface. The calculation of likelihoods for a phylogeny in the presence and absence of selection, permits the application of a likelihood ratio test to search for selection. It is shown that even a single selected site can have a strong effect on the likelihood. The method is illustrated with an example fromDrosophila melanogaster and suggests that delerious selection may be acting on transposable elements. IS - 6 JF - Journal of Molecular Evolution EP - 523 TI - A maximum likelihood approach to the detection of selection from a phylogeny VL - 31 SP - 511 AU - Golding, Brian AU - Felsenstein, Joe PY - 1990/12/01/ UR - http://dx.doi.org/10.1007/BF02102078 ER -