The presence of vesicoureteric reflux does not identify a population at risk for renal scarring following a first urinary tract infection. Export

@article{citeulike:1095773, abstract = {BACKGROUND: Childhood urinary tract infection (UTI) with or without vesicoureteric reflux (VUR) may predispose to renal scarring. There is no clear consensus in the literature regarding imaging following UTI in infancy. AIMS: To define the role of cystography following a first UTI in children aged under 1 year, when urinary tract ultrasonography (US) is normal. METHODS: Retrospective data collection of 108 children (216 renal units) aged under 1 year at the time of a bacteriologically proven UTI. All had a normal US and underwent both catheter cystogram and DMSA test. Sensitivity, specificity, likelihood ratios positive and negative, and diagnostic odds ratio were calculated for VUR on cystography versus scarring on DMSA. RESULTS: VUR was shown in 25 (11.6\%) renal units. Scarring on DMSA was seen in 8 (3.7 \%) kidneys. Only 16\% of kidneys with VUR had associated scarring; 50\% of scarred kidneys were not associated with VUR. The likelihood ratio positive was 4.95 (95\% CI 2.22 to 11.05) and the likelihood ratio negative was 0.56 (95\% CI 0.28 to 1.11). The diagnostic odds ratio was 8.9, suggesting that cystography provided little additional information. CONCLUSION: Since only 16\% of children with VUR had an abnormal kidney, the presence of VUR does not identify a susceptible population with an abnormal kidney on DMSA. In the context of a normal ultrasound examination, cystography contributes little to the management of children under the age of 1 year with a UTI. In this context, a normal DMSA study reinforces the redundancy of cystography.}, address = {Department of Clinical Radiology, Great Ormond Street Hospital for Children, London, UK. jimandima@aol.com}, author = {Moorthy, I. and Easty, M. and McHugh, K. and Ridout, D. and Biassoni, L. and Gordon, I.}, citeulike-article-id = {1095773}, citeulike-linkout-0 = {http://dx.doi.org/10.1136/adc.2004.057604}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15970618}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15970618}, comment = {similar rates of scars with and without reflux}, doi = {10.1136/adc.2004.057604}, issn = {1468-2044}, journal = {Arch Dis Child}, keywords = {key, reflux, scars}, month = {July}, number = {7}, pages = {733--736}, posted-at = {2007-02-08 23:26:29}, priority = {2}, title = {The presence of vesicoureteric reflux does not identify a population at risk for renal scarring following a first urinary tract infection.}, url = {http://dx.doi.org/10.1136/adc.2004.057604}, volume = {90}, year = {2005} }

TY - JOUR ID - citeulike:1095773 L3 - citeulike-article-id:1095773 N2 - BACKGROUND: Childhood urinary tract infection (UTI) with or without vesicoureteric reflux (VUR) may predispose to renal scarring. There is no clear consensus in the literature regarding imaging following UTI in infancy. AIMS: To define the role of cystography following a first UTI in children aged under 1 year, when urinary tract ultrasonography (US) is normal. METHODS: Retrospective data collection of 108 children (216 renal units) aged under 1 year at the time of a bacteriologically proven UTI. All had a normal US and underwent both catheter cystogram and DMSA test. Sensitivity, specificity, likelihood ratios positive and negative, and diagnostic odds ratio were calculated for VUR on cystography versus scarring on DMSA. RESULTS: VUR was shown in 25 (11.6%) renal units. Scarring on DMSA was seen in 8 (3.7 %) kidneys. Only 16% of kidneys with VUR had associated scarring; 50% of scarred kidneys were not associated with VUR. The likelihood ratio positive was 4.95 (95% CI 2.22 to 11.05) and the likelihood ratio negative was 0.56 (95% CI 0.28 to 1.11). The diagnostic odds ratio was 8.9, suggesting that cystography provided little additional information. CONCLUSION: Since only 16% of children with VUR had an abnormal kidney, the presence of VUR does not identify a susceptible population with an abnormal kidney on DMSA. In the context of a normal ultrasound examination, cystography contributes little to the management of children under the age of 1 year with a UTI. In this context, a normal DMSA study reinforces the redundancy of cystography. IS - 7 JF - Arch Dis Child SN - 1468-2044 AD - Department of Clinical Radiology, Great Ormond Street Hospital for Children, London, UK. jimandima@aol.com EP - 736 TI - The presence of vesicoureteric reflux does not identify a population at risk for renal scarring following a first urinary tract infection. VL - 90 SP - 733 KW - key KW - reflux KW - scars N1 - similar rates of scars with and without reflux AU - Moorthy, I AU - Easty, M AU - McHugh, K AU - Ridout, D AU - Biassoni, L AU - Gordon, I PY - 2005/07// UR - http://dx.doi.org/10.1136/adc.2004.057604 ER -