Vesicoureteral reflux increases the risk of renal scars: a study of unilateral reflux. Export

@article{citeulike:1095776, abstract = {The aim of this study was to assess the impact of vesicoureteral reflux (VUR) on renal scar following acute pyelonephritis by comparing the refluxing renal units with nonrefluxing renal units in children with unilateral primary VUR. Forty-eight children with unilateral primary VUR diagnosed after the first pyelonephritis were enrolled. Mean age of patients was 1.0+/-1.6 years (29 boys and 19 girls). All patients underwent renal ultrasonography and renal 99 m-technetium dimercaptosuccinic acid (DMSA) scan within three days following the diagnosis of pyelonephritis, and voiding cystourethrography (VCU) was performed soon after fever subsided and the infection was controlled. The DMSA scan was rechecked six months after the initial study when the first scan showed a renal defect. The first DMSA showed renal defects in 34 (70.8\%) out of 48 of the refluxing renal units and in 13 (27.1\%) out of 48 of the nonrefluxing renal units (P<0.01, OR: 6.54). At six months after the infection, 23 (47.9\%) out of 48 refluxing renal units and seven (14.6\%) out of 48 nonrefluxing renal units had renal scars on DMSA scan (P<0.01, OR: 5.39). The prevalence of renal scars did not vary significantly according to the grade of VUR. The CRP level on admission was significantly higher in patients with acute renal defect and scar. In conclusion, VUR increases the risk of post-pyelonephritic renal scars in children.}, address = {Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.}, author = {Lee, J. H. and Son, C. H. and Lee, M. S. and Park, Y. S.}, citeulike-article-id = {1095776}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00467-006-0147-x}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16791609}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16791609}, comment = {unilateral reflux increased risk of scars x2}, doi = {10.1007/s00467-006-0147-x}, issn = {0931-041X}, journal = {Pediatr Nephrol}, keywords = {key, reflux, scars}, month = {September}, number = {9}, pages = {1281--1284}, posted-at = {2007-02-08 23:29:24}, priority = {2}, title = {Vesicoureteral reflux increases the risk of renal scars: a study of unilateral reflux.}, url = {http://dx.doi.org/10.1007/s00467-006-0147-x}, volume = {21}, year = {2006} }

TY - JOUR ID - citeulike:1095776 L3 - citeulike-article-id:1095776 N2 - The aim of this study was to assess the impact of vesicoureteral reflux (VUR) on renal scar following acute pyelonephritis by comparing the refluxing renal units with nonrefluxing renal units in children with unilateral primary VUR. Forty-eight children with unilateral primary VUR diagnosed after the first pyelonephritis were enrolled. Mean age of patients was 1.0+/-1.6 years (29 boys and 19 girls). All patients underwent renal ultrasonography and renal 99 m-technetium dimercaptosuccinic acid (DMSA) scan within three days following the diagnosis of pyelonephritis, and voiding cystourethrography (VCU) was performed soon after fever subsided and the infection was controlled. The DMSA scan was rechecked six months after the initial study when the first scan showed a renal defect. The first DMSA showed renal defects in 34 (70.8%) out of 48 of the refluxing renal units and in 13 (27.1%) out of 48 of the nonrefluxing renal units (P<0.01, OR: 6.54). At six months after the infection, 23 (47.9%) out of 48 refluxing renal units and seven (14.6%) out of 48 nonrefluxing renal units had renal scars on DMSA scan (P<0.01, OR: 5.39). The prevalence of renal scars did not vary significantly according to the grade of VUR. The CRP level on admission was significantly higher in patients with acute renal defect and scar. In conclusion, VUR increases the risk of post-pyelonephritic renal scars in children. IS - 9 JF - Pediatr Nephrol SN - 0931-041X AD - Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. EP - 1284 TI - Vesicoureteral reflux increases the risk of renal scars: a study of unilateral reflux. VL - 21 SP - 1281 KW - key KW - reflux KW - scars N1 - unilateral reflux increased risk of scars x2 AU - Lee, JH AU - Son, CH AU - Lee, MS AU - Park, YS PY - 2006/09// UR - http://dx.doi.org/10.1007/s00467-006-0147-x ER -