Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord. Export

@article{citeulike:103077, abstract = {Dorsal commissural axons in the developing spinal cord cross the floor plate, then turn rostrally and grow along the longitudinal axis, close to the floor plate. We used a subtractive hybridization approach to identify guidance cues responsible for the rostral turn in chicken embryos. One of the candidates was the morphogen Sonic hedgehog (Shh). Silencing of the gene SHH (which encodes Shh) by in ovo RNAi during commissural axon navigation demonstrated a repulsive role in post-commissural axon guidance. This effect of Shh was not mediated by Patched (Ptc) and Smoothened (Smo), the receptors that mediate effects of Shh in morphogenesis and commissural axon growth toward the floor plate. Rather, functional in vivo studies showed that the repulsive effect of Shh on postcommissural axons was mediated by Hedgehog interacting protein (Hip).}, address = {[1] University of Zurich, Institute of Zoology, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. [2] These authors contributed equally to this work.}, author = {Bourikas, Dimitris and Pekarik, Vladimir and Baeriswyl, Thomas and Grunditz, Asa and Sadhu, Rejina and Nard\'{o}, Michele and Stoeckli, Esther T T.}, citeulike-article-id = {103077}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nn1396}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15682187}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15682187}, day = {30}, doi = {10.1038/nn1396}, issn = {1097-6256}, journal = {Nat Neurosci}, keywords = {axon-guidance, neural-tube, shh}, month = {January}, posted-at = {2005-05-16 17:42:45}, priority = {2}, title = {Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord.}, url = {http://dx.doi.org/10.1038/nn1396}, year = {2005} }

TY - JOUR ID - citeulike:103077 L3 - citeulike-article-id:103077 N2 - Dorsal commissural axons in the developing spinal cord cross the floor plate, then turn rostrally and grow along the longitudinal axis, close to the floor plate. We used a subtractive hybridization approach to identify guidance cues responsible for the rostral turn in chicken embryos. One of the candidates was the morphogen Sonic hedgehog (Shh). Silencing of the gene SHH (which encodes Shh) by in ovo RNAi during commissural axon navigation demonstrated a repulsive role in post-commissural axon guidance. This effect of Shh was not mediated by Patched (Ptc) and Smoothened (Smo), the receptors that mediate effects of Shh in morphogenesis and commissural axon growth toward the floor plate. Rather, functional in vivo studies showed that the repulsive effect of Shh on postcommissural axons was mediated by Hedgehog interacting protein (Hip). JF - Nat Neurosci SN - 1097-6256 AD - [1] University of Zurich, Institute of Zoology, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. [2] These authors contributed equally to this work. TI - Sonic hedgehog guides commissural axons along the longitudinal axis of the spinal cord. KW - axon-guidance KW - neural-tube KW - shh AU - Bourikas, Dimitris AU - Pekarik, Vladimir AU - Baeriswyl, Thomas AU - Grunditz, Asa AU - Sadhu, Rejina AU - Nardó, Michele AU - Stoeckli, Esther T PY - 2005/01/30/ UR - http://dx.doi.org/10.1038/nn1396 ER -