Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas Export

@article{St-Onge1997, abstract = {The functional unit of the endocrine pancreas is the islet of Langerhans. Islets are nested within the exocrine tissue of the pancreas and are composed of alpha-, beta-, delta- and gamma-cells. beta-Cells produce insulin and form the core of the islet, whereas alpha-, delta- and gamma-cells are arranged at the periphery of the islet and secrete glucagon, somatostatin and a pancreatic polypeptide, respectively. Little is known about the molecular and genetic factors regulating the lineage of the different endocrine cells. Pancreas development is known to be abolished in Pdx1-mutant mice and Pax4 mutants lack insulin-producing beta-cells. Here we show that the paired-box gene Pax6 is expressed during the early stages of pancreatic development and in mature endocrine cells. The pancreas of Pax6 homozygous mutant mice lack glucagon-producing cells, suggesting that Pax6 is essential for the differentiation of alpha-cells. As mice lacking Pax4 and Pax6 fail to develop any mature endocrine cells, we conclude that both Pax genes are required for endocrine fate in the pancreas.}, author = {St Onge, L. S. and Pineda, B. Sosa and Chowdhury, K. and Mansouri, A. and Gruss, P.}, citeulike-article-id = {168219}, journal = {Nature}, keywords = {alpha-cell, bibtex-import, islet, pancreas, pax6}, number = {6631}, pages = {406--9}, posted-at = {2005-04-23 06:42:38}, priority = {0}, title = {Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas}, volume = {387}, year = {1997} }

TY - JOUR ID - St-Onge1997 L3 - citeulike-article-id:168219 N2 - The functional unit of the endocrine pancreas is the islet of Langerhans. Islets are nested within the exocrine tissue of the pancreas and are composed of alpha-, beta-, delta- and gamma-cells. beta-Cells produce insulin and form the core of the islet, whereas alpha-, delta- and gamma-cells are arranged at the periphery of the islet and secrete glucagon, somatostatin and a pancreatic polypeptide, respectively. Little is known about the molecular and genetic factors regulating the lineage of the different endocrine cells. Pancreas development is known to be abolished in Pdx1-mutant mice and Pax4 mutants lack insulin-producing beta-cells. Here we show that the paired-box gene Pax6 is expressed during the early stages of pancreatic development and in mature endocrine cells. The pancreas of Pax6 homozygous mutant mice lack glucagon-producing cells, suggesting that Pax6 is essential for the differentiation of alpha-cells. As mice lacking Pax4 and Pax6 fail to develop any mature endocrine cells, we conclude that both Pax genes are required for endocrine fate in the pancreas. IS - 6631 JF - Nature EP - 9 TI - Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas VL - 387 SP - 406 KW - alpha-cell KW - bibtex-import KW - islet KW - pancreas KW - pax6 AU - St Onge, LS AU - Pineda, Sosa AU - Chowdhury, K AU - Mansouri, A AU - Gruss, P PY - 1997/// ER -