Navigating the pathway from embryonic stem cells to beta cells. Export

@article{citeulike:172401, abstract = {The compelling goal of using in vitro differentiation of stem cells to obtain replacement pancreatic beta cells that are clinically effective in treating diabetes has until now eluded researchers. This difficulty raises the question of whether more effective strategies are available. We propose that the native embryonic pathway leading to the definitive endoderm lineage, and continuing on to the endocrine pancreas, is the one most likely to succeed for the in vitro differentiation of embryonic stem cells. We question however whether gain-of-function approaches involving genes necessary for beta cell development are destined to work effectively, and suggest alternative approaches to identifying conditions sufficient for in vitro beta cell differentiation.}, address = {Laboratory of Metabolic Diseases, The Rockefeller University, New York, NY 10021, USA. stoffel@rockefeller.edu}, author = {Stoffel, M. and Vallier, L. and Pedersen, R. A.}, citeulike-article-id = {172401}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.semcdb.2004.02.002}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15125896}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15125896}, doi = {10.1016/j.semcdb.2004.02.002}, issn = {1084-9521}, journal = {Semin Cell Dev Biol}, keywords = {beta-cell, diabetes, pancreas, stem-cell}, month = {June}, number = {3}, pages = {327--336}, posted-at = {2005-04-27 17:05:26}, priority = {5}, title = {Navigating the pathway from embryonic stem cells to beta cells.}, url = {http://dx.doi.org/10.1016/j.semcdb.2004.02.002}, volume = {15}, year = {2004} }

TY - JOUR ID - citeulike:172401 L3 - citeulike-article-id:172401 N2 - The compelling goal of using in vitro differentiation of stem cells to obtain replacement pancreatic beta cells that are clinically effective in treating diabetes has until now eluded researchers. This difficulty raises the question of whether more effective strategies are available. We propose that the native embryonic pathway leading to the definitive endoderm lineage, and continuing on to the endocrine pancreas, is the one most likely to succeed for the in vitro differentiation of embryonic stem cells. We question however whether gain-of-function approaches involving genes necessary for beta cell development are destined to work effectively, and suggest alternative approaches to identifying conditions sufficient for in vitro beta cell differentiation. IS - 3 JF - Semin Cell Dev Biol SN - 1084-9521 AD - Laboratory of Metabolic Diseases, The Rockefeller University, New York, NY 10021, USA. stoffel@rockefeller.edu EP - 336 TI - Navigating the pathway from embryonic stem cells to beta cells. VL - 15 SP - 327 KW - beta-cell KW - diabetes KW - pancreas KW - stem-cell AU - Stoffel, M AU - Vallier, L AU - Pedersen, RA PY - 2004/06// UR - http://dx.doi.org/10.1016/j.semcdb.2004.02.002 ER -