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Costal-2: a scaffold for kinases mediates Hedgehog signaling. Export

Dev Cell, Vol. 8, No. 2. (February 2005), pp. 140-141.

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cos2 hedgehog

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Drosophila genetics has identified several components of the Hedgehog signaling pathway, but the mechanism by which they act remains elusive. In this issue of Developmental Cell, a report by Zhang et al. provides evidence that the kinesin-related protein Costal-2 forms a multi-component scaffold that mediates Hedgehog signaling.


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