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A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched. Export

Nature, Vol. 341, No. 6242. (12 October 1989), pp. 508-513.

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The patterning of cells in insect segments requires the exchange of information between cells, which in Drosophila depends on the activity of members of the segment-polarity class of genes. Here we report the molecular characterization of one such gene, patched. We find that patched encodes a large protein with several possible membrane-spanning domains and is expressed in a complex pattern during embryogenesis.


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