HNF-3 beta is essential for node and notochord formation in mouse development. Export

@article{citeulike:241058, abstract = {HNF-3 beta, a member of the HNF-3/fork head family of transcription factors, is expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of this gene leads to embryonic lethality. The primary defect of HNF-3 beta -/- embryos is an absence of organized node and notochord formation, which leads to secondary defects in dorsal-ventral patterning of the neural tube. In contrast, patterning along the anterior-posterior axis was surprisingly little affected. Although HNF-3 beta is required for node and notochord formation, some organizer activity persists in the absence of these structures. HNF-3 beta is not required for the development of definitive endoderm cells, but foregut morphogenesis is severely affected in HNF-3 beta -/- embryos.}, address = {Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.}, author = {Ang, S. L. and Rossant, J.}, citeulike-article-id = {241058}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8069909}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8069909}, day = {26}, issn = {0092-8674}, journal = {Cell}, keywords = {foxa2, knockout}, month = {August}, number = {4}, pages = {561--574}, posted-at = {2005-06-30 19:36:42}, priority = {2}, title = {HNF-3 beta is essential for node and notochord formation in mouse development.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8069909}, volume = {78}, year = {1994} }

TY - JOUR ID - citeulike:241058 L3 - citeulike-article-id:241058 N2 - HNF-3 beta, a member of the HNF-3/fork head family of transcription factors, is expressed in the node, notochord, floor plate, and gut in mouse embryos. A null mutation of this gene leads to embryonic lethality. The primary defect of HNF-3 beta -/- embryos is an absence of organized node and notochord formation, which leads to secondary defects in dorsal-ventral patterning of the neural tube. In contrast, patterning along the anterior-posterior axis was surprisingly little affected. Although HNF-3 beta is required for node and notochord formation, some organizer activity persists in the absence of these structures. HNF-3 beta is not required for the development of definitive endoderm cells, but foregut morphogenesis is severely affected in HNF-3 beta -/- embryos. IS - 4 JF - Cell SN - 0092-8674 AD - Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. EP - 574 TI - HNF-3 beta is essential for node and notochord formation in mouse development. VL - 78 SP - 561 KW - foxa2 KW - knockout AU - Ang, SL AU - Rossant, J PY - 1994/08/26/ UR - http://view.ncbi.nlm.nih.gov/pubmed/8069909 ER -