Dynamic DNA methylation programs persistent adverse effects of early-life stress Export

@article{citeulike:6087936, abstract = {Adverse early life events can induce long-lasting changes in physiology and behavior. We found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone and alterations in passive stress coping and memory. This phenotype was accompanied by a persistent increase in arginine vasopressin (AVP) expression in neurons of the hypothalamic paraventricular nucleus and was reversed by an AVP receptor antagonist. Altered Avp expression was associated with sustained DNA hypomethylation of an important regulatory region that resisted age-related drifts in methylation and centered on those CpG residues that serve as DNA-binding sites for the methyl CpG–binding protein 2 (MeCP2). We found that neuronal activity controlled the ability of MeCP2 to regulate activity-dependent transcription of the Avp gene and induced epigenetic marking. Thus, ELS can dynamically control DNA methylation in postmitotic neurons to generate stable changes in Avp expression that trigger neuroendocrine and behavioral alterations that are frequent features in depression.}, author = {Murgatroyd, Chris and Patchev, Alexandre V. and Wu, Yonghe and Micale, Vincenzo and Bockmuhl, Yvonne and Fischer, Dieter and Holsboer, Florian and Wotjak, Carsten T. and Almeida, Osborne F. X. and Spengler, Dietmar}, citeulike-article-id = {6087936}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nn.2436}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nn.2436}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19898468}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19898468}, day = {08}, doi = {10.1038/nn.2436}, issn = {1097-6256}, journal = {Nature Neuroscience}, keywords = {epigenetics, maternalcare, maternaldeprivation, mice, stress}, month = {November}, number = {12}, pages = {1559--1566}, posted-at = {2009-11-09 12:45:11}, priority = {2}, publisher = {Nature Publishing Group}, title = {Dynamic DNA methylation programs persistent adverse effects of early-life stress}, url = {http://dx.doi.org/10.1038/nn.2436}, volume = {12}, year = {2009} }

TY - JOUR ID - citeulike:6087936 L3 - citeulike-article-id:6087936 N2 - Adverse early life events can induce long-lasting changes in physiology and behavior. We found that early-life stress (ELS) in mice caused enduring hypersecretion of corticosterone and alterations in passive stress coping and memory. This phenotype was accompanied by a persistent increase in arginine vasopressin (AVP) expression in neurons of the hypothalamic paraventricular nucleus and was reversed by an AVP receptor antagonist. Altered Avp expression was associated with sustained DNA hypomethylation of an important regulatory region that resisted age-related drifts in methylation and centered on those CpG residues that serve as DNA-binding sites for the methyl CpG–binding protein 2 (MeCP2). We found that neuronal activity controlled the ability of MeCP2 to regulate activity-dependent transcription of the Avp gene and induced epigenetic marking. Thus, ELS can dynamically control DNA methylation in postmitotic neurons to generate stable changes in Avp expression that trigger neuroendocrine and behavioral alterations that are frequent features in depression. IS - 12 JF - Nature Neuroscience SN - 1097-6256 EP - 1566 TI - Dynamic DNA methylation programs persistent adverse effects of early-life stress PB - Nature Publishing Group VL - 12 SP - 1559 KW - epigenetics KW - maternalcare KW - maternaldeprivation KW - mice KW - stress AU - Murgatroyd, Chris AU - Patchev, Alexandre AU - Wu, Yonghe AU - Micale, Vincenzo AU - Bockmuhl, Yvonne AU - Fischer, Dieter AU - Holsboer, Florian AU - Wotjak, Carsten AU - Almeida, Osborne AU - Spengler, Dietmar PY - 2009/11/08/ UR - http://dx.doi.org/10.1038/nn.2436 ER -