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Nature, Vol. 408, No. 6810. (16 November 2000), pp. 307-310, doi:10.1038/35042675 Key: citeulike:239628
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The p53 tumour-suppressor gene integrates numerous signals that control cell life and death. As when a highly connected node in the Internet breaks down, the disruption of p53 has severe consequences. Tumour-suppressor genes are needed to keep cells under control. Just as a car's brakes regulate its speed, properly functioning tumour-suppressor genes act as brakes to the cycle of cell growth, DNA replication and division into two new cells.
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