A unification of mosaic structures in the human genome. Export

@article{citeulike:1088242, abstract = {The human genome is a mosaic structure on many levels: there exist cytogenetic bands, GC composition bands (isochores) and clusters of broadly expressed genes. How might these inter-relate? It has been proposed that to optimize gene regulation, housekeeping genes should concentrate on transcriptionally competent chromosomal domains. Prior evidence suggests that regions of high GC and R bands are associated with such domains. Here we report that broadly expressed genes cluster in regions of high GC, and in R and lightest Giemsa bands. This is not only a confirmation of the adaptive hypothesis, but is also the first direct systematic evidence of a general interdependence of expression patterns with base composition and chromosome structure.}, address = {Department of Biology and Biochemistry, University of Bath, UK. m.j.lercher@bath.ac.uk}, author = {Lercher, M. J. and Urrutia, A. O. and Pavl\'{\i}cek, A. and Hurst, L. D.}, citeulike-article-id = {1088242}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12915446}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12915446}, day = {1}, issn = {0964-6906}, journal = {Hum Mol Genet}, month = {October}, number = {19}, pages = {2411--2415}, posted-at = {2007-02-05 11:11:09}, priority = {2}, title = {A unification of mosaic structures in the human genome.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12915446}, volume = {12}, year = {2003} }

TY - JOUR ID - citeulike:1088242 L3 - citeulike-article-id:1088242 N2 - The human genome is a mosaic structure on many levels: there exist cytogenetic bands, GC composition bands (isochores) and clusters of broadly expressed genes. How might these inter-relate? It has been proposed that to optimize gene regulation, housekeeping genes should concentrate on transcriptionally competent chromosomal domains. Prior evidence suggests that regions of high GC and R bands are associated with such domains. Here we report that broadly expressed genes cluster in regions of high GC, and in R and lightest Giemsa bands. This is not only a confirmation of the adaptive hypothesis, but is also the first direct systematic evidence of a general interdependence of expression patterns with base composition and chromosome structure. IS - 19 JF - Hum Mol Genet SN - 0964-6906 AD - Department of Biology and Biochemistry, University of Bath, UK. m.j.lercher@bath.ac.uk EP - 2415 TI - A unification of mosaic structures in the human genome. VL - 12 SP - 2411 AU - Lercher, MJ AU - Urrutia, AO AU - Pavlícek, A AU - Hurst, LD PY - 2003/10/01/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12915446 ER -