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Vaccines: Self-amplifying RNA in lipid nanoparticles: a next-generation vaccine?

by: Alexandra Flemming
Nat Rev Drug Discov, Vol. 11, No. 10. (01 October 2012), pp. 748-749, doi:10.1038/nrd3854  Key: citeulike:11410687

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Abstract

Vaccines based on nucleic acids (both DNA and RNA) have been investigated for several decades, but have not yet resulted in a commercial product for human use. Now, reporting in PNAS, Geall and colleagues present a new vaccine platform based on self-amplifying RNA encapsulated


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