Intracellular acidosis enhances the excitability of working muscle. Export

@article{citeulike:615604, abstract = {Intracellular acidification of skeletal muscles is commonly thought to contribute to muscle fatigue. However, intracellular acidosis also acts to preserve muscle excitability when muscles become depolarized, which occurs with working muscles. Here, we show that this process may be mediated by decreased chloride permeability, which enables action potentials to still be propagated along the internal network of tubules in a muscle fiber (the T system) despite muscle depolarization. These results implicate chloride ion channels in muscle function and emphasize that intracellular acidosis of muscle has protective effects during muscle fatigue.}, address = {Department of Physiology, University of Aarhus, DK-8000, Denmark.}, author = {Pedersen, T. H. and Nielsen, O. B. and Lamb, G. D. and Stephenson, D. G.}, citeulike-article-id = {615604}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1101141}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15326352}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15326352}, day = {20}, doi = {10.1126/science.1101141}, issn = {1095-9203}, journal = {Science}, keywords = {acidose, lactate}, month = {August}, number = {5687}, pages = {1144--1147}, posted-at = {2006-05-06 00:01:34}, priority = {0}, title = {Intracellular acidosis enhances the excitability of working muscle.}, url = {http://dx.doi.org/10.1126/science.1101141}, volume = {305}, year = {2004} }

TY - JOUR ID - citeulike:615604 L3 - citeulike-article-id:615604 N2 - Intracellular acidification of skeletal muscles is commonly thought to contribute to muscle fatigue. However, intracellular acidosis also acts to preserve muscle excitability when muscles become depolarized, which occurs with working muscles. Here, we show that this process may be mediated by decreased chloride permeability, which enables action potentials to still be propagated along the internal network of tubules in a muscle fiber (the T system) despite muscle depolarization. These results implicate chloride ion channels in muscle function and emphasize that intracellular acidosis of muscle has protective effects during muscle fatigue. IS - 5687 JF - Science SN - 1095-9203 AD - Department of Physiology, University of Aarhus, DK-8000, Denmark. EP - 1147 TI - Intracellular acidosis enhances the excitability of working muscle. VL - 305 SP - 1144 KW - acidose KW - lactate AU - Pedersen, TH AU - Nielsen, OB AU - Lamb, GD AU - Stephenson, DG PY - 2004/08/20/ UR - http://dx.doi.org/10.1126/science.1101141 ER -