Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. Export

@article{citeulike:2924440, abstract = {The epsilon 4 allele of apolipoprotein E (apoE) is a major risk factor for Alzheimer disease, suggesting that apoE may directly influence neurons in the aging brain. Recent data suggest that apoE-containing lipoproteins can influence neurite outgrowth in an isoform-specific fashion. The neuronal mediators of apoE effects have not been clarified. We show here that in a central nervous system-derived neuronal cell line, apoE3 but not apoE4 increases neurite extension. The effect of apoE3 was blocked at low nanomolar concentrations by purified 39-kDa protein that regulates ligand binding to the low density lipoprotein receptor-related protein (LRP). Anti-LRP antibody also completely abolished the neurite-promoting effect of apoE3. Understanding isoform-specific cell biological processes mediated by apoE-LRP interactions in central nervous system neurons may provide insight into Alzheimer disease pathogenesis.}, address = {Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.}, author = {Holtzman, D. M. and Pitas, R. E. and Kilbridge, J. and Nathan, B. and Mahley, R. W. and Bu, G. and Schwartz, A. L.}, citeulike-article-id = {2924440}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/7568158}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=7568158}, day = {10}, issn = {0027-8424}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {apoe, gt1-1, invitro, outgrowth, plasticity, polymorphism, receptors}, month = {October}, number = {21}, pages = {9480--9484}, posted-at = {2008-06-24 22:59:02}, priority = {0}, title = {Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/7568158}, volume = {92}, year = {1995} }

TY - JOUR ID - citeulike:2924440 L3 - citeulike-article-id:2924440 N2 - The epsilon 4 allele of apolipoprotein E (apoE) is a major risk factor for Alzheimer disease, suggesting that apoE may directly influence neurons in the aging brain. Recent data suggest that apoE-containing lipoproteins can influence neurite outgrowth in an isoform-specific fashion. The neuronal mediators of apoE effects have not been clarified. We show here that in a central nervous system-derived neuronal cell line, apoE3 but not apoE4 increases neurite extension. The effect of apoE3 was blocked at low nanomolar concentrations by purified 39-kDa protein that regulates ligand binding to the low density lipoprotein receptor-related protein (LRP). Anti-LRP antibody also completely abolished the neurite-promoting effect of apoE3. Understanding isoform-specific cell biological processes mediated by apoE-LRP interactions in central nervous system neurons may provide insight into Alzheimer disease pathogenesis. IS - 21 JF - Proceedings of the National Academy of Sciences of the United States of America SN - 0027-8424 AD - Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. EP - 9484 TI - Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line. VL - 92 SP - 9480 KW - apoe KW - gt1-1 KW - invitro KW - outgrowth KW - plasticity KW - polymorphism KW - receptors AU - Holtzman, DM AU - Pitas, RE AU - Kilbridge, J AU - Nathan, B AU - Mahley, RW AU - Bu, G AU - Schwartz, AL PY - 1995/10/10/ UR - http://view.ncbi.nlm.nih.gov/pubmed/7568158 ER -