[Absorption, transport and bio-availability of iodothyronines] Export

@article{citeulike:3149690, abstract = {The frequently prescribed classical thyroid hormones (iodothyronines) are critical dose drugs with a narrow therapeutic index. Nowadays the mechanisms of their absorption, which takes place predominantly in the jejunum and ileum, have only partly been elucidated. Bioavailability of iodothyronines whose kinetics is subject to enterohepatic circulation, is about 70 \%. Several factors influence their absorption including nutrients, drugs and concomitant diseases. After being absorbed only a small fraction of thyroid hormones circulates freely in plasma, whereas the greater portion is bound to plasma proteins. This binding, too, may be influenced by numerous factors; alterations by certain diseases and physiological conditions may lead to ambiguities in differential diagnosis. Intracellular accumulation of iodothyronines is accomplished by at least ten different active and energy-dependent transporters with variable tissue distribution. Particularly in critical illness (non-thyroidal illness syndrome) alterations of protein binding and membrane transport are common. In therapy of hypothyroid patients different brand-name products lack bioequivalence and thus requiring subsequent monitoring of thyroid status after treatment has been changed among different brand-name versions.}, address = {Medizinische Klinik I, Universit\"{a}tsklinikum Bergmannsheil, Ruhr-Universit\"{a}t Bochum. johannes.w.dietrich@bergmannsheil.de}, author = {Dietrich, J. W. and Brisseau, K. and Boehm, B. O.}, citeulike-article-id = {3149690}, citeulike-linkout-0 = {http://dx.doi.org/10.1055/s-0028-1082780}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18651367}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18651367}, comment = {German title: "Resorption, Transport und Bioverf\"{u}gbarkeit von Schilddr\"{u}senhormonen"}, doi = {10.1055/s-0028-1082780}, issn = {1439-4413}, journal = {Deutsche medizinische Wochenschrift (1946)}, keywords = {clinical-thyroidology, endocrinology, klinische-thyreologie}, month = {August}, number = {31-32}, pages = {1644--1648}, posted-at = {2008-08-22 17:34:07}, priority = {0}, title = {[Absorption, transport and bio-availability of iodothyronines]}, url = {http://dx.doi.org/10.1055/s-0028-1082780}, volume = {133}, year = {2008} }

TY - JOUR ID - citeulike:3149690 L3 - citeulike-article-id:3149690 N2 - The frequently prescribed classical thyroid hormones (iodothyronines) are critical dose drugs with a narrow therapeutic index. Nowadays the mechanisms of their absorption, which takes place predominantly in the jejunum and ileum, have only partly been elucidated. Bioavailability of iodothyronines whose kinetics is subject to enterohepatic circulation, is about 70 %. Several factors influence their absorption including nutrients, drugs and concomitant diseases. After being absorbed only a small fraction of thyroid hormones circulates freely in plasma, whereas the greater portion is bound to plasma proteins. This binding, too, may be influenced by numerous factors; alterations by certain diseases and physiological conditions may lead to ambiguities in differential diagnosis. Intracellular accumulation of iodothyronines is accomplished by at least ten different active and energy-dependent transporters with variable tissue distribution. Particularly in critical illness (non-thyroidal illness syndrome) alterations of protein binding and membrane transport are common. In therapy of hypothyroid patients different brand-name products lack bioequivalence and thus requiring subsequent monitoring of thyroid status after treatment has been changed among different brand-name versions. IS - 31-32 JF - Deutsche medizinische Wochenschrift (1946) SN - 1439-4413 AD - Medizinische Klinik I, Universitätsklinikum Bergmannsheil, Ruhr-Universität Bochum. johannes.w.dietrich@bergmannsheil.de EP - 1648 TI - [Absorption, transport and bio-availability of iodothyronines] VL - 133 SP - 1644 KW - clinical-thyroidology KW - endocrinology KW - klinische-thyreologie N1 - German title: "Resorption, Transport und Bioverfügbarkeit von Schilddrüsenhormonen" AU - Dietrich, JW AU - Brisseau, K AU - Boehm, BO PY - 2008/08// UR - http://dx.doi.org/10.1055/s-0028-1082780 ER -