Activity in the gastrointestinal tract after administration of bone-seeking radiopharmaceuticals. Experimental studies in mice.

@article{citeulike:604382, abstract = {PURPOSE: To test the possibility that (radio)activity of non-pertechnetate nature is excreted into the gastrointestinal tract at bone scintigraphy. MATERIAL AND METHODS: The distribution of a bone-seeking radiopharmaceutical (99mTc-HDP) was studied in an experimental mouse system by dissecting different organs and assessing their activity with a gamma-counter. RESULTS: A comparison of the activity of the submandibular glands, which are assumed to accumulate only pertechnetate, and the gastrointestinal tract showed that a significant fraction of the activity excreted into the gastrointestinal tract did not consist of pertechnetate. Part of the excretion took place in the stomach. It was not connected to a specific bone-seeking agent or 99Mo/99mTc generator. Nor did it increase with time between make-up and injection. The excretion of the non-pertechnetate activity was reduced by cimetidine and omeprazole. These gastric-secretion blocking drugs did not reduce excretion of pertechnetate or significantly affect the general distribution of the radiopharmaceutical. CONCLUSION: There is a significant excretion of non-pertechnetate activity in the gastrointestinal tract. Part of this may be caused by excretion of the undegraded radiopharmaceutical by the stomach mucosa.}, address = {Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden.}, author = {Cronhjort, M. and Jonsson, C. and Nilsson, S. O. and Garmelius, B. and Jacobsson, H.}, citeulike-article-id = {604382}, issn = {0284-1851}, journal = {Acta Radiol}, keywords = {omeprazole, technetium}, month = {September}, number = {5}, pages = {785--790}, posted-at = {2006-04-27 14:31:37}, priority = {0}, title = {Activity in the gastrointestinal tract after administration of bone-seeking radiopharmaceuticals. Experimental studies in mice.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8915294}, volume = {37}, year = {1996} }

TY - JOUR ID - citeulike:604382 L3 - citeulike-article-id:604382 N2 - PURPOSE: To test the possibility that (radio)activity of non-pertechnetate nature is excreted into the gastrointestinal tract at bone scintigraphy. MATERIAL AND METHODS: The distribution of a bone-seeking radiopharmaceutical (99mTc-HDP) was studied in an experimental mouse system by dissecting different organs and assessing their activity with a gamma-counter. RESULTS: A comparison of the activity of the submandibular glands, which are assumed to accumulate only pertechnetate, and the gastrointestinal tract showed that a significant fraction of the activity excreted into the gastrointestinal tract did not consist of pertechnetate. Part of the excretion took place in the stomach. It was not connected to a specific bone-seeking agent or 99Mo/99mTc generator. Nor did it increase with time between make-up and injection. The excretion of the non-pertechnetate activity was reduced by cimetidine and omeprazole. These gastric-secretion blocking drugs did not reduce excretion of pertechnetate or significantly affect the general distribution of the radiopharmaceutical. CONCLUSION: There is a significant excretion of non-pertechnetate activity in the gastrointestinal tract. Part of this may be caused by excretion of the undegraded radiopharmaceutical by the stomach mucosa. IS - 5 JF - Acta Radiol SN - 0284-1851 AD - Department of Diagnostic Radiology, Karolinska Hospital, Stockholm, Sweden. EP - 790 TI - Activity in the gastrointestinal tract after administration of bone-seeking radiopharmaceuticals. Experimental studies in mice. VL - 37 SP - 785 KW - omeprazole KW - technetium AU - Cronhjort, M AU - Jonsson, C AU - Nilsson, SO AU - Garmelius, B AU - Jacobsson, H PY - 1996/09// UR - http://view.ncbi.nlm.nih.gov/pubmed/8915294 ER -