Combination of vitamin K2 and the angiotensin-converting enzyme inhibitor, perindopril, attenuates the liver enzyme-altered preneoplastic lesions in rats via angiogenesis suppression. Export

@article{citeulike:608364, abstract = {BACKGROUND/AIMS: Chemoprevention should be a promising approach to improve the prognosis of the patients with hepatocellular carcinoma (HCC). Angiogenesis is now recognized as a crucial step not only in tumor growth, but also in early carcinogenesis. The aim of this study was to elucidate the combination effect of the clinically used vitamin K(2) (VK) and the angiotensin-converting enzyme inhibitor, perindopril (PE), on hepatocarcinogenesis, especially in conjunction with angiogenesis. METHODS: In a diethylnitrosamine-induced rat hepatocarcinogenesis model, the effects of VK and PE on the development of liver enzyme-altered preneoplastic lesions and angiogenesis were examined. RESULTS: Treatment with both VK and PE markedly inhibited the development of preneoplastic lesions in association with suppression of neovascularization in the liver. The combination treatment with VK and PE exerted a more potent inhibitory effect as compared with the single agent treatments. The in vitro study demonstrated that VK and PE inhibited the endothelial cell (EC) tubular formation. VK also suppressed the EC proliferation in a dose-dependent manner. CONCLUSIONS: The combination of VK and PE exerted a chemopreventive effect against rat liver carcinogenesis via suppression of angiogenesis. Since both agents are widely used in the clinical practice, this combination therapy may represent a potential new strategy for chemoprevention against HCC in the future.}, address = {Third Department of Internal Medicine, Nara Medical University, Shijo-cho 840, Kashihara, Nara 634-8522, Japan. yoshijih@naramed-u.ac.jp}, author = {Yoshiji, H. and Kuriyama, S. and Noguchi, R. and Yoshii, J. and Ikenaka, Y. and Yanase, K. and Namisaki, T. and Kitade, M. and Yamazaki, M. and Masaki, T. and Fukui, H.}, citeulike-article-id = {608364}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.jhep.2004.12.025}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15826718}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15826718}, comment = {末次 2回目}, doi = {10.1016/j.jhep.2004.12.025}, issn = {0168-8278}, journal = {J Hepatol}, keywords = {ace-inhibitor, angiogenesis, carcinoma, hepatocellular, menaquinone, perindopril, seminar, vitamink}, month = {May}, number = {5}, pages = {687--693}, posted-at = {2006-05-01 03:02:45}, priority = {0}, title = {Combination of vitamin K2 and the angiotensin-converting enzyme inhibitor, perindopril, attenuates the liver enzyme-altered preneoplastic lesions in rats via angiogenesis suppression.}, url = {http://dx.doi.org/10.1016/j.jhep.2004.12.025}, volume = {42}, year = {2005} }

TY - JOUR ID - citeulike:608364 L3 - citeulike-article-id:608364 N2 - BACKGROUND/AIMS: Chemoprevention should be a promising approach to improve the prognosis of the patients with hepatocellular carcinoma (HCC). Angiogenesis is now recognized as a crucial step not only in tumor growth, but also in early carcinogenesis. The aim of this study was to elucidate the combination effect of the clinically used vitamin K(2) (VK) and the angiotensin-converting enzyme inhibitor, perindopril (PE), on hepatocarcinogenesis, especially in conjunction with angiogenesis. METHODS: In a diethylnitrosamine-induced rat hepatocarcinogenesis model, the effects of VK and PE on the development of liver enzyme-altered preneoplastic lesions and angiogenesis were examined. RESULTS: Treatment with both VK and PE markedly inhibited the development of preneoplastic lesions in association with suppression of neovascularization in the liver. The combination treatment with VK and PE exerted a more potent inhibitory effect as compared with the single agent treatments. The in vitro study demonstrated that VK and PE inhibited the endothelial cell (EC) tubular formation. VK also suppressed the EC proliferation in a dose-dependent manner. CONCLUSIONS: The combination of VK and PE exerted a chemopreventive effect against rat liver carcinogenesis via suppression of angiogenesis. Since both agents are widely used in the clinical practice, this combination therapy may represent a potential new strategy for chemoprevention against HCC in the future. IS - 5 JF - J Hepatol SN - 0168-8278 AD - Third Department of Internal Medicine, Nara Medical University, Shijo-cho 840, Kashihara, Nara 634-8522, Japan. yoshijih@naramed-u.ac.jp EP - 693 TI - Combination of vitamin K2 and the angiotensin-converting enzyme inhibitor, perindopril, attenuates the liver enzyme-altered preneoplastic lesions in rats via angiogenesis suppression. VL - 42 SP - 687 KW - ace-inhibitor KW - angiogenesis KW - carcinoma KW - hepatocellular KW - menaquinone KW - perindopril KW - seminar KW - vitamink N1 - 末次 2回目 AU - Yoshiji, H AU - Kuriyama, S AU - Noguchi, R AU - Yoshii, J AU - Ikenaka, Y AU - Yanase, K AU - Namisaki, T AU - Kitade, M AU - Yamazaki, M AU - Masaki, T AU - Fukui, H PY - 2005/05// UR - http://dx.doi.org/10.1016/j.jhep.2004.12.025 ER -