Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation. Export

@article{citeulike:608375, abstract = {Hepatocellular carcinoma (HCC) is a common human malignancy. Its high mortality rate is mainly a result of high intrahepatic recurrence and portal venous invasion (PVI). We previously reported that the development of PVI is related to levels of des-gamma-carboxy prothrombin (DCP), a serum protein that increases at a notably higher rate in patients with HCC. Because DCP is produced by a vitamin K shortage, we examined the biological effects of extrinsic supplementation of vitamin K(2) in HCC cells in vitro and in vivo. Consequently, vitamin K(2) inhibits the growth and invasion of HCC cells through the activation of protein kinase A, which modulates the activities of several transcriptional factors and inhibits the small GTPase Rho, independent of suppression of DCP. In addition, administration of vitamin K(2) to nude mice inoculated with liver tumor cells reduced both tumor growth and body weight loss. In conclusion, similar to an acyclic retinoid--which was previously reported to prevent the recurrence of HCC--vitamin K(2), another lipid-soluble vitamin, may be a promising therapeutic means for the management of HCC.}, address = {Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.}, author = {Otsuka, M. and Kato, N. and Shao, R. X. and Hoshida, Y. and Ijichi, H. and Koike, Y. and Taniguchi, H. and Moriyama, M. and Shiratori, Y. and Kawabe, T. and Omata, M.}, citeulike-article-id = {608375}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/hep.20260}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15239108}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15239108}, comment = {渡瀬 1回目}, doi = {10.1002/hep.20260}, issn = {0270-9139}, journal = {Hepatology}, keywords = {anticancer, hepatocellular, menaquinone, seminar, vitamink}, month = {July}, number = {1}, pages = {243--251}, posted-at = {2006-05-01 03:31:45}, priority = {0}, title = {Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation.}, url = {http://dx.doi.org/10.1002/hep.20260}, volume = {40}, year = {2004} }

TY - JOUR ID - citeulike:608375 L3 - citeulike-article-id:608375 N2 - Hepatocellular carcinoma (HCC) is a common human malignancy. Its high mortality rate is mainly a result of high intrahepatic recurrence and portal venous invasion (PVI). We previously reported that the development of PVI is related to levels of des-gamma-carboxy prothrombin (DCP), a serum protein that increases at a notably higher rate in patients with HCC. Because DCP is produced by a vitamin K shortage, we examined the biological effects of extrinsic supplementation of vitamin K(2) in HCC cells in vitro and in vivo. Consequently, vitamin K(2) inhibits the growth and invasion of HCC cells through the activation of protein kinase A, which modulates the activities of several transcriptional factors and inhibits the small GTPase Rho, independent of suppression of DCP. In addition, administration of vitamin K(2) to nude mice inoculated with liver tumor cells reduced both tumor growth and body weight loss. In conclusion, similar to an acyclic retinoid--which was previously reported to prevent the recurrence of HCC--vitamin K(2), another lipid-soluble vitamin, may be a promising therapeutic means for the management of HCC. IS - 1 JF - Hepatology SN - 0270-9139 AD - Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. EP - 251 TI - Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation. VL - 40 SP - 243 KW - anticancer KW - hepatocellular KW - menaquinone KW - seminar KW - vitamink N1 - 渡瀬 1回目 AU - Otsuka, M AU - Kato, N AU - Shao, RX AU - Hoshida, Y AU - Ijichi, H AU - Koike, Y AU - Taniguchi, H AU - Moriyama, M AU - Shiratori, Y AU - Kawabe, T AU - Omata, M PY - 2004/07// UR - http://dx.doi.org/10.1002/hep.20260 ER -