Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis. Export

@article{citeulike:616971, abstract = {The isoprenoid pathway, by its end-products lipids, has an important role in the control of ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis. In particular, prenylation, a post-translational addition of farnesol and geranylgeraniol, is an important event for the biological activity of many proteins that play critical roles in signal transduction and cytoskeletal regulation, as well as in cell proliferation and apoptosis. We have been interested in studying the: (a) regulation of the isoprenoid pathway in the processing of cellular transformation induced by the K-ras oncogene, (b) role of the isoprenoid pathway in the control of cell proliferation and apoptosis, (c) role of the isoprenoid pathway in the control of cytoskeleton organization and (d) control of Rab expression by the isoprenoid pathway.}, address = {Dipartimento di Scienze Farmaceutiche, Universit\`{a} degli Studi di Salerno, via Ponte Don Melillo 84084, Fisciano, Salerno, Italy. maubiful@unina.it}, author = {Bifulco, M.}, citeulike-article-id = {616971}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.lfs.2005.05.017}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15955538}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15955538}, day = {19}, doi = {10.1016/j.lfs.2005.05.017}, issn = {0024-3205}, journal = {Life Sci}, keywords = {apoptosis, geranylgeraniol, isoprenoid, ras}, month = {August}, number = {14}, pages = {1740--1749}, posted-at = {2006-05-08 05:06:11}, priority = {0}, title = {Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis.}, url = {http://dx.doi.org/10.1016/j.lfs.2005.05.017}, volume = {77}, year = {2005} }

TY - JOUR ID - citeulike:616971 L3 - citeulike-article-id:616971 N2 - The isoprenoid pathway, by its end-products lipids, has an important role in the control of ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis. In particular, prenylation, a post-translational addition of farnesol and geranylgeraniol, is an important event for the biological activity of many proteins that play critical roles in signal transduction and cytoskeletal regulation, as well as in cell proliferation and apoptosis. We have been interested in studying the: (a) regulation of the isoprenoid pathway in the processing of cellular transformation induced by the K-ras oncogene, (b) role of the isoprenoid pathway in the control of cell proliferation and apoptosis, (c) role of the isoprenoid pathway in the control of cytoskeleton organization and (d) control of Rab expression by the isoprenoid pathway. IS - 14 JF - Life Sci SN - 0024-3205 AD - Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, via Ponte Don Melillo 84084, Fisciano, Salerno, Italy. maubiful@unina.it EP - 1749 TI - Role of the isoprenoid pathway in ras transforming activity, cytoskeleton organization, cell proliferation and apoptosis. VL - 77 SP - 1740 KW - apoptosis KW - geranylgeraniol KW - isoprenoid KW - ras AU - Bifulco, M PY - 2005/08/19/ UR - http://dx.doi.org/10.1016/j.lfs.2005.05.017 ER -