Inhibition of neuronal dopamine uptake by some antiallergic drugs. Export

@article{citeulike:625155, abstract = {The effects of 10 antiallergic drugs (astemizole, azelastine, ebastine, emedastine, epinastine, ketotifen, oxatomide, terfenadine, pemirolast and tranilast) on neuronal dopamine uptake were examined. Some drugs examined showed a concentration-dependent inhibition of [3H]dopamine uptake into synaptosomal preparations of the rat striatum. The inhibition constant (Ki) values were 231-876 nM for ebastine, terfenadine, oxatomide and astemizole. The specific binding of [3H] (1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine) (GBR12935) to the rat striatal membranes was also inhibited by these antiallergic drugs. There was a good correlation between the degrees of inhibition of [3H]dopamine uptake and [3H]GBR12935 binding. Then, the behavioral excitement induced by L-DOPA (100 mg/kg, s.c.) plus pargyline hydrochloride (80 mg/kg, i.p.) in mice was significantly enhanced by i.p. treatment with ebastine (10 mg/kg) and astemizole (5 mg/kg). These results suggest that the neuronal dopamine uptake is inhibited by some antiallergic drugs, especially ebastine.}, address = {Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka, Japan.}, author = {Matsunaga, K. and Sato, T. and Shuto, H. and Tsuruta, Y. and Suemaru, K. and Gomita, Y. and Oishi, R.}, citeulike-article-id = {625155}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/9696404}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=9696404}, day = {5}, issn = {0014-2999}, journal = {Eur J Pharmacol}, keywords = {antiallergic, dopamine}, month = {June}, number = {2-3}, pages = {165--169}, posted-at = {2006-05-12 14:46:56}, priority = {0}, title = {Inhibition of neuronal dopamine uptake by some antiallergic drugs.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/9696404}, volume = {350}, year = {1998} }

TY - JOUR ID - citeulike:625155 L3 - citeulike-article-id:625155 N2 - The effects of 10 antiallergic drugs (astemizole, azelastine, ebastine, emedastine, epinastine, ketotifen, oxatomide, terfenadine, pemirolast and tranilast) on neuronal dopamine uptake were examined. Some drugs examined showed a concentration-dependent inhibition of [3H]dopamine uptake into synaptosomal preparations of the rat striatum. The inhibition constant (Ki) values were 231-876 nM for ebastine, terfenadine, oxatomide and astemizole. The specific binding of [3H] (1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine) (GBR12935) to the rat striatal membranes was also inhibited by these antiallergic drugs. There was a good correlation between the degrees of inhibition of [3H]dopamine uptake and [3H]GBR12935 binding. Then, the behavioral excitement induced by L-DOPA (100 mg/kg, s.c.) plus pargyline hydrochloride (80 mg/kg, i.p.) in mice was significantly enhanced by i.p. treatment with ebastine (10 mg/kg) and astemizole (5 mg/kg). These results suggest that the neuronal dopamine uptake is inhibited by some antiallergic drugs, especially ebastine. IS - 2-3 JF - Eur J Pharmacol SN - 0014-2999 AD - Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka, Japan. EP - 169 TI - Inhibition of neuronal dopamine uptake by some antiallergic drugs. VL - 350 SP - 165 KW - antiallergic KW - dopamine AU - Matsunaga, K AU - Sato, T AU - Shuto, H AU - Tsuruta, Y AU - Suemaru, K AU - Gomita, Y AU - Oishi, R PY - 1998/06/05/ UR - http://view.ncbi.nlm.nih.gov/pubmed/9696404 ER -