Vitamin E isoforms alpha-tocotrienol and gamma-tocopherol prevent cerebral infarction in mice. Export

@article{citeulike:625180, abstract = {Alpha-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in the mice middle cerebral artery (MCA) occlusion model. All vitamin E isoforms were injected i.v., twice, immediately before and 3 h after the occlusion. Alpha-tocopherol (2 mM), alpha-tocotrienol (0.2 and 2 mM) and gamma-tocopherol (0.2 and 2 mM) significantly decreased the size of the cerebral infarcts 1 day after the MCA occlusion, while gamma-tocotrienol, delta-tocopherol and delta-tocotrienol showed no effect on the cerebral infarcts. These results suggest that alpha-tocotrienol and gamma-tocopherol are potent and effective agents for preventing cerebral infarction induced by MCA occlusion.}, address = {Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.}, author = {Mishima, K. and Tanaka, T. and Pu, F. and Egashira, N. and Iwasaki, K. and Hidaka, R. and Matsunaga, K. and Takata, J. and Karube, Y. and Fujiwara, M.}, citeulike-article-id = {625180}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/12524170}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=12524170}, day = {30}, issn = {0304-3940}, journal = {Neurosci Lett}, keywords = {tocopherol, tocotrienol, vitamine}, month = {January}, number = {1}, pages = {56--60}, posted-at = {2006-05-12 14:52:11}, priority = {0}, title = {Vitamin E isoforms alpha-tocotrienol and gamma-tocopherol prevent cerebral infarction in mice.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12524170}, volume = {337}, year = {2003} }

TY - JOUR ID - citeulike:625180 L3 - citeulike-article-id:625180 N2 - Alpha-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the ischemic brain damage in the mice middle cerebral artery (MCA) occlusion model. All vitamin E isoforms were injected i.v., twice, immediately before and 3 h after the occlusion. Alpha-tocopherol (2 mM), alpha-tocotrienol (0.2 and 2 mM) and gamma-tocopherol (0.2 and 2 mM) significantly decreased the size of the cerebral infarcts 1 day after the MCA occlusion, while gamma-tocotrienol, delta-tocopherol and delta-tocotrienol showed no effect on the cerebral infarcts. These results suggest that alpha-tocotrienol and gamma-tocopherol are potent and effective agents for preventing cerebral infarction induced by MCA occlusion. IS - 1 JF - Neurosci Lett SN - 0304-3940 AD - Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan. EP - 60 TI - Vitamin E isoforms alpha-tocotrienol and gamma-tocopherol prevent cerebral infarction in mice. VL - 337 SP - 56 KW - tocopherol KW - tocotrienol KW - vitamine AU - Mishima, K AU - Tanaka, T AU - Pu, F AU - Egashira, N AU - Iwasaki, K AU - Hidaka, R AU - Matsunaga, K AU - Takata, J AU - Karube, Y AU - Fujiwara, M PY - 2003/01/30/ UR - http://view.ncbi.nlm.nih.gov/pubmed/12524170 ER -