Potentiation of L-dopa-induced behavioral excitement by histamine H1-receptor antagonists in mice. Export

@article{citeulike:625198, abstract = {Effects of histamine H1-receptor antagonists on L-dopa-induced behavioral excitement were examined in mice to confirm behaviorally the inhibition of dopamine uptake by these compounds. L-Dopa (100-300 mg/kg, s.c.) combined with pargyline hydrochloride (80 mg/kg, i.p.) caused a dose-dependent behavioral excitement. The marked excitement induced by L-dopa (300 mg/kg) plus pargyline was significantly inhibited by pimozide (0.1 - 1 mg/kg, s.c.), a selective dopamine antagonist. Tripelennamine (10 mg/kg, s.c.), d-chlorpheniramine (1 and 2 mg/kg, s.c.), homochlorcyclizine (2 and 5 mg/kg, s.c.), diphenhydramine (2 and 5 mg/kg, s.c.) and mepyramine (2 and 5 mg/kg, s.c.) each markedly enhanced the moderate behavioral excitement induced by L-dopa (150 mg/kg) plus pargyline. These findings are behavioral evidence for inhibition of dopamine uptake by H1 antagonists, which has been suggested by neurochemical studies.}, address = {Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka, Japan.}, author = {Sato, T. and Suemaru, K. and Matsunaga, K. and Hamaoka, S. and Gomita, Y. and Oishi, R.}, citeulike-article-id = {625198}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8791174}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8791174}, issn = {0021-5198}, journal = {Jpn J Pharmacol}, keywords = {histamine, l-dopa}, month = {May}, number = {1}, pages = {81--84}, posted-at = {2006-05-12 15:01:55}, priority = {0}, title = {Potentiation of L-dopa-induced behavioral excitement by histamine H1-receptor antagonists in mice.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8791174}, volume = {71}, year = {1996} }

TY - JOUR ID - citeulike:625198 L3 - citeulike-article-id:625198 N2 - Effects of histamine H1-receptor antagonists on L-dopa-induced behavioral excitement were examined in mice to confirm behaviorally the inhibition of dopamine uptake by these compounds. L-Dopa (100-300 mg/kg, s.c.) combined with pargyline hydrochloride (80 mg/kg, i.p.) caused a dose-dependent behavioral excitement. The marked excitement induced by L-dopa (300 mg/kg) plus pargyline was significantly inhibited by pimozide (0.1 - 1 mg/kg, s.c.), a selective dopamine antagonist. Tripelennamine (10 mg/kg, s.c.), d-chlorpheniramine (1 and 2 mg/kg, s.c.), homochlorcyclizine (2 and 5 mg/kg, s.c.), diphenhydramine (2 and 5 mg/kg, s.c.) and mepyramine (2 and 5 mg/kg, s.c.) each markedly enhanced the moderate behavioral excitement induced by L-dopa (150 mg/kg) plus pargyline. These findings are behavioral evidence for inhibition of dopamine uptake by H1 antagonists, which has been suggested by neurochemical studies. IS - 1 JF - Jpn J Pharmacol SN - 0021-5198 AD - Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka, Japan. EP - 84 TI - Potentiation of L-dopa-induced behavioral excitement by histamine H1-receptor antagonists in mice. VL - 71 SP - 81 KW - histamine KW - l-dopa AU - Sato, T AU - Suemaru, K AU - Matsunaga, K AU - Hamaoka, S AU - Gomita, Y AU - Oishi, R PY - 1996/05// UR - http://view.ncbi.nlm.nih.gov/pubmed/8791174 ER -