Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes? Export

@article{citeulike:764553, abstract = {The concentrations of lipid-soluble, chain-breaking antioxidants in human plasma and in erythrocyte ghosts have been determined for the first time by an inhibited-autoxidation method. The results are very similar to the concentrations of vitamin E measured for the same blood components by the HPLC method. It is concluded that vitamin E, which is largely present as [alpha]-tocopherol, is the only significant lipid-soluble, chain-breaking type of antioxidant present in human blood. The concentration of vitamin E-in the plasma lipids divided by the concentration of vitamin E in the ghost membrane lipids is approximately a constant despite the large differences in vitamin E-intake and in plasma lipid concentrations in different individuals. Vitamin E/lipid ratios for plasma and ghosts were larger for subjects taking a supplement of [alpha]-tocopherol acetate of 100 IU per week, compared to nonsupplemented subjects (based on data from a limited number of subjects). A larger supplement of 2800 IU per week did not significantly increase the vitamin E/lipid ratios.}, author = {Burton, Graham W. and Joyce, Anne and Ingold, Keith U.}, citeulike-article-id = {764553}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/0003-9861(83)90145-5}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6WB5-4DN433J-5B/2/5dcc30e17c0027cdc2bfaab35f68d098}, day = {15}, doi = {10.1016/0003-9861(83)90145-5}, journal = {Archives of Biochemistry and Biophysics}, keywords = {tocopherol}, month = {February}, number = {1}, pages = {281--290}, posted-at = {2006-07-19 13:08:28}, priority = {2}, title = {Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?}, url = {http://dx.doi.org/10.1016/0003-9861(83)90145-5}, volume = {221}, year = {1983} }

TY - JOUR ID - citeulike:764553 L3 - citeulike-article-id:764553 N2 - The concentrations of lipid-soluble, chain-breaking antioxidants in human plasma and in erythrocyte ghosts have been determined for the first time by an inhibited-autoxidation method. The results are very similar to the concentrations of vitamin E measured for the same blood components by the HPLC method. It is concluded that vitamin E, which is largely present as [alpha]-tocopherol, is the only significant lipid-soluble, chain-breaking type of antioxidant present in human blood. The concentration of vitamin E-in the plasma lipids divided by the concentration of vitamin E in the ghost membrane lipids is approximately a constant despite the large differences in vitamin E-intake and in plasma lipid concentrations in different individuals. Vitamin E/lipid ratios for plasma and ghosts were larger for subjects taking a supplement of [alpha]-tocopherol acetate of 100 IU per week, compared to nonsupplemented subjects (based on data from a limited number of subjects). A larger supplement of 2800 IU per week did not significantly increase the vitamin E/lipid ratios. IS - 1 JF - Archives of Biochemistry and Biophysics EP - 290 TI - Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes? VL - 221 SP - 281 KW - tocopherol AU - Burton, Graham AU - Joyce, Anne AU - Ingold, Keith PY - 1983/02/15/ UR - http://dx.doi.org/10.1016/0003-9861(83)90145-5 ER -