Working memory for conjunctions relies on the medial temporal lobe. Export

@article{citeulike:603331, abstract = {A prominent theory of hippocampal function proposes that the hippocampus is importantly involved in relating or binding together separate pieces of information to form an episodic representation. This hypothesis has only been applied to studies of long-term memory because the paradigmatic view of the hippocampus is that it is not critical for short-term forms of memory. However, relational processing is important in many working memory tasks, especially tasks using visual stimuli. Here, we test the hypothesis that the medial temporal lobes are important for relational memory even over short delays. The task required patients with medial temporal lobe amnesia and controls to remember three objects, locations, or object-location conjunctions over 1 or 8 s delays. The results show that working memory for objects and locations was at normal levels, but that memory for conjunctions was severely impaired at 8 s delays. Additional analyses suggest that the hippocampus per se is critical for accurate conjunction working memory. We propose that the hippocampus is critically involved in memory for conjunctions at both short and long delays.}, author = {Olson, Ingrid R. and Page, Katie and Moore, Katherine Sledge S. and Chatterjee, Anjan and Verfaellie, Mieke}, citeulike-article-id = {603331}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.1923}, citeulike-linkout-1 = {http://www.jneurosci.org/cgi/content/abstract/26/17/4596}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/16641239}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=16641239}, day = {26}, doi = {10.1523/JNEUROSCI.1923}, issn = {1529-2401}, journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience}, keywords = {amnesia, binding, brain\_injury, brain\_organization, cp\_prosem, hippocampus, memory, temporal\_lobe, working\_memory}, month = {April}, number = {17}, pages = {4596--4601}, posted-at = {2009-09-30 20:59:12}, priority = {0}, title = {Working memory for conjunctions relies on the medial temporal lobe.}, url = {http://dx.doi.org/10.1523/JNEUROSCI.1923}, volume = {26}, year = {2006} }

TY - JOUR ID - citeulike:603331 L3 - citeulike-article-id:603331 N2 - A prominent theory of hippocampal function proposes that the hippocampus is importantly involved in relating or binding together separate pieces of information to form an episodic representation. This hypothesis has only been applied to studies of long-term memory because the paradigmatic view of the hippocampus is that it is not critical for short-term forms of memory. However, relational processing is important in many working memory tasks, especially tasks using visual stimuli. Here, we test the hypothesis that the medial temporal lobes are important for relational memory even over short delays. The task required patients with medial temporal lobe amnesia and controls to remember three objects, locations, or object-location conjunctions over 1 or 8 s delays. The results show that working memory for objects and locations was at normal levels, but that memory for conjunctions was severely impaired at 8 s delays. Additional analyses suggest that the hippocampus per se is critical for accurate conjunction working memory. We propose that the hippocampus is critically involved in memory for conjunctions at both short and long delays. IS - 17 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience SN - 1529-2401 EP - 4601 TI - Working memory for conjunctions relies on the medial temporal lobe. VL - 26 SP - 4596 KW - amnesia KW - binding KW - brain_injury KW - brain_organization KW - cp_prosem KW - hippocampus KW - memory KW - temporal_lobe KW - working_memory AU - Olson, Ingrid AU - Page, Katie AU - Moore, Katherine Sledge AU - Chatterjee, Anjan AU - Verfaellie, Mieke PY - 2006/04/26/ UR - http://dx.doi.org/10.1523/JNEUROSCI.1923 ER -