Micro magnetic stir-bar mixer integrated with parylene microfluidic channels

@article{citeulike:2570576, abstract = {Previously, we reported a micro magnetic stir-bar mixer driven by an external rotating magnetic field and its rapid mixing performance in polydimethyl-siloxane (PDMS) channels. The PDMS piece with embedded fluid channels were manually aligned to a glass substrate and assembled. In this paper, we report the fabrication and testing results of a micro magnetic stir-bar monolithically integrated in parylene surface-micromachined channels with improved design features, including small tolerance of the stir-bar to channel wall (10 ?). Using of parylene based microchannels with improved design not only provides improved mixing, but also eliminates certain problems associated with PDMS-based channels. For example, porosity of PDMS causes evaporation and absorption of chemicals and thus channels made of PDMS are prone to cross-contamination. We have also demonstrated that the magnetic stir-bar can be used to pump liquid in micro channels.}, address = {Micro and Nanotechnology Laboratory, University of Illinois, 208 North Wright St., Urbana, IL 61801, United States}, author = {Ryu, K. S. and Shaikh, K. and Goluch, E. and Fan, Z. and Liu, C.}, citeulike-article-id = {2570576}, doi = {10.1039/b403305a}, journal = {Lab Chip Miniaturisation Chem. Biol.}, keywords = {microfluidic-mixers, microfluidics}, number = {6}, pages = {608--613}, posted-at = {2008-03-21 19:37:36}, priority = {0}, title = {Micro magnetic stir-bar mixer integrated with parylene microfluidic channels}, url = {http://dx.doi.org/10.1039/b403305a}, volume = {4}, year = {2004} }

TY - JOUR ID - citeulike:2570576 L3 - citeulike-article-id:2570576 N2 - Previously, we reported a micro magnetic stir-bar mixer driven by an external rotating magnetic field and its rapid mixing performance in polydimethyl-siloxane (PDMS) channels. The PDMS piece with embedded fluid channels were manually aligned to a glass substrate and assembled. In this paper, we report the fabrication and testing results of a micro magnetic stir-bar monolithically integrated in parylene surface-micromachined channels with improved design features, including small tolerance of the stir-bar to channel wall (10 ?). Using of parylene based microchannels with improved design not only provides improved mixing, but also eliminates certain problems associated with PDMS-based channels. For example, porosity of PDMS causes evaporation and absorption of chemicals and thus channels made of PDMS are prone to cross-contamination. We have also demonstrated that the magnetic stir-bar can be used to pump liquid in micro channels. IS - 6 JF - Lab Chip Miniaturisation Chem. Biol. AD - Micro and Nanotechnology Laboratory, University of Illinois, 208 North Wright St., Urbana, IL 61801, United States EP - 613 TI - Micro magnetic stir-bar mixer integrated with parylene microfluidic channels VL - 4 SP - 608 KW - microfluidic-mixers KW - microfluidics AU - Ryu, KS AU - Shaikh, K AU - Goluch, E AU - Fan, Z AU - Liu, C PY - 2004/// UR - http://dx.doi.org/10.1039/b403305a ER -