Flagellin gene sequence evolution in Salmonella Export

@article{flg-seq-evol, abstract = {Salmonella exhibits 70 serologically distinct flagellins, used internationally to diagnose and track infections. The terminal sequences of flagellin protein subunits are conserved in a range of bacteria and are here used as evolutionary markers to reveal how new serotypes arise. Terminal sequences of flagellins that exhibit factors g or m (G-group) were distinct from other Salmonella antigens (Non-G-group) and cluster more closely with Escherichia coli . It is postulated that G-group flagellins were inherited from a common ancestor of E. coli and Salmonella and that these antigens were among the original set in Salmonella . Sequence differences at the 5′ termini may prevent recombination between co-infecting strains. Evidence of increased variation of flagellin in rare biphasic G-group serotypes suggests that the presence of a second flagellin locus allows mutation of the G-group flagellin. FljB probably arose from a single duplication of a Non-G gene, since which synonymous mutations resulted in the fljB -specific sequence at the 5′ termini.}, author = {Mortimer, C. and Gharbia, S. and Logan, J. and Peters, T. and Arnold, C.}, citeulike-article-id = {5178439}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.meegid.2006.12.001}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S1567134806001432}, doi = {10.1016/j.meegid.2006.12.001}, issn = {15671348}, journal = {Infection, Genetics and Evolution}, keywords = {evolution, flagellin, salmonella}, month = {July}, number = {4}, pages = {411--415}, posted-at = {2009-07-16 13:18:00}, priority = {2}, title = {Flagellin gene sequence evolution in Salmonella}, url = {http://dx.doi.org/10.1016/j.meegid.2006.12.001}, volume = {7}, year = {2007} }

TY - JOUR ID - flg-seq-evol L3 - citeulike-article-id:5178439 N2 - Salmonella exhibits 70 serologically distinct flagellins, used internationally to diagnose and track infections. The terminal sequences of flagellin protein subunits are conserved in a range of bacteria and are here used as evolutionary markers to reveal how new serotypes arise. Terminal sequences of flagellins that exhibit factors g or m (G-group) were distinct from other Salmonella antigens (Non-G-group) and cluster more closely with Escherichia coli . It is postulated that G-group flagellins were inherited from a common ancestor of E. coli and Salmonella and that these antigens were among the original set in Salmonella . Sequence differences at the 5′ termini may prevent recombination between co-infecting strains. Evidence of increased variation of flagellin in rare biphasic G-group serotypes suggests that the presence of a second flagellin locus allows mutation of the G-group flagellin. FljB probably arose from a single duplication of a Non-G gene, since which synonymous mutations resulted in the fljB -specific sequence at the 5′ termini. IS - 4 JF - Infection, Genetics and Evolution SN - 15671348 EP - 415 TI - Flagellin gene sequence evolution in Salmonella VL - 7 SP - 411 KW - evolution KW - flagellin KW - salmonella AU - Mortimer, C AU - Gharbia, S AU - Logan, J AU - Peters, T AU - Arnold, C PY - 2007/07// UR - http://dx.doi.org/10.1016/j.meegid.2006.12.001 ER -