THE ETIOLOGY OF FEBRILE ILLNESS IN ADULTS PRESENTING TO PATAN HOSPITAL IN KATHMANDU, NEPAL Export

@article{febrile-nepal-2004, abstract = {In Nepal, many infections remain poorly characterized, partly due to limited diagnostic facilities. We studied consecutive febrile adults presenting to a general hospital in Kathmandu, Nepal. Of the 876 patients enrolled, enteric fever and pneumonia were the most common clinical diagnoses. Putative pathogens were identified in 323 (37\%) patients, the most common being Salmonella enterica serotype Typhi and S. enterica serotype Paratyphi A (117), Rickettsia typhi (97), Streptococcus pneumoniae (53), Leptospira spp. (36), and Orientia tsutsugamushi (28). Approximately half of the Salmonella isolates were resistant to nalidixic acid. No clinical predictors were identified to reliably distinguish between the different infections. These findings confirm the heavy burden of enteric fever and pneumonia in Kathmandu, and highlight the importance of murine typhus, scrub typhus, and leptospirosis. Given the lack of reliable clinical predictors, the development of cheap and accurate diagnostic tests are likely to be of great clinical utility in this setting.}, author = {Murdoch, David R. and Woods, Christopher W. and Zimmerman, Mark D. and Dull, Peter M. and Belbase, Ram H. A. R. I. and Keenan, Andrew J. and Scott, Robert M. C. N. A. I. R. and Basnyat, Buddha and Archibald, Lennox K. and Reller, L. Barth}, citeulike-article-id = {5202365}, citeulike-linkout-0 = {http://www.ajtmh.org/cgi/content/abstract/70/6/670}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15211012}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15211012}, day = {1}, journal = {Am J Trop Med Hyg}, month = {June}, number = {6}, pages = {670--675}, posted-at = {2009-07-19 13:39:32}, priority = {2}, title = {THE ETIOLOGY OF FEBRILE ILLNESS IN ADULTS PRESENTING TO PATAN HOSPITAL IN KATHMANDU, NEPAL}, url = {http://www.ajtmh.org/cgi/content/abstract/70/6/670}, volume = {70}, year = {2004} }

TY - JOUR ID - febrile-nepal-2004 L3 - citeulike-article-id:5202365 N2 - In Nepal, many infections remain poorly characterized, partly due to limited diagnostic facilities. We studied consecutive febrile adults presenting to a general hospital in Kathmandu, Nepal. Of the 876 patients enrolled, enteric fever and pneumonia were the most common clinical diagnoses. Putative pathogens were identified in 323 (37%) patients, the most common being Salmonella enterica serotype Typhi and S. enterica serotype Paratyphi A (117), Rickettsia typhi (97), Streptococcus pneumoniae (53), Leptospira spp. (36), and Orientia tsutsugamushi (28). Approximately half of the Salmonella isolates were resistant to nalidixic acid. No clinical predictors were identified to reliably distinguish between the different infections. These findings confirm the heavy burden of enteric fever and pneumonia in Kathmandu, and highlight the importance of murine typhus, scrub typhus, and leptospirosis. Given the lack of reliable clinical predictors, the development of cheap and accurate diagnostic tests are likely to be of great clinical utility in this setting. IS - 6 JF - Am J Trop Med Hyg EP - 675 TI - THE ETIOLOGY OF FEBRILE ILLNESS IN ADULTS PRESENTING TO PATAN HOSPITAL IN KATHMANDU, NEPAL VL - 70 SP - 670 AU - Murdoch, David AU - Woods, Christopher AU - Zimmerman, Mark AU - Dull, Peter AU - Belbase, Ram AU - Keenan, Andrew AU - Scott, Robert AU - Basnyat, Buddha AU - Archibald, Lennox AU - Reller, Barth PY - 2004/06/01/ UR - http://www.ajtmh.org/cgi/content/abstract/70/6/670 ER -